Spermatogenesis: the commitment to meiosis

MD Griswold - Physiological reviews, 2016 - journals.physiology.org
Mammalian spermatogenesis requires a stem cell pool, a period of amplification of cell
numbers, the completion of reduction division to haploid cells (meiosis), and the …

Spermatogenesis in humans and its affecting factors

FTL Neto, PV Bach, BB Najari, PS Li… - Seminars in cell & …, 2016 - Elsevier
Spermatogenesis is an extraordinary complex process. The differentiation of spermatogonia
into spermatozoa requires the participation of several cell types, hormones, paracrine …

A comprehensive roadmap of murine spermatogenesis defined by single-cell RNA-seq

CD Green, Q Ma, GL Manske, AN Shami, X Zheng… - Developmental cell, 2018 - cell.com
Spermatogenesis requires intricate interactions between the germline and somatic cells.
Within a given cross section of a seminiferous tubule, multiple germ and somatic cell types …

Variation in cancer risk among tissues can be explained by the number of stem cell divisions

C Tomasetti, B Vogelstein - Science, 2015 - science.org
Some tissue types give rise to human cancers millions of times more often than other tissue
types. Although this has been recognized for more than a century, it has never been …

The nature and dynamics of spermatogonial stem cells

DG De Rooij - Development, 2017 - journals.biologists.com
Spermatogonial stem cells (SSCs) are crucial for maintaining spermatogenesis throughout
life, and understanding how these cells function has important implications for …
C Ernst, N Eling, CP Martinez-Jimenez… - Nature …, 2019 - nature.com
Male gametes are generated through a specialised differentiation pathway involving a
series of developmental transitions that are poorly characterised at the molecular level …

The blood-testis barrier and its implications for male contraception

CY Cheng, DD Mruk - Pharmacological reviews, 2012 - Elsevier
The blood-testis barrier (BTB) is one of the tightest blood-tissue barriers in the mammalian
body. It divides the seminiferous epithelium into the basal and the apical (adluminal) …

Spermatogenesis in fish

RW Schulz, LR de França, JJ Lareyre, F LeGac… - General and …, 2010 - Elsevier
Spermatogenesis is a developmental process during which a small number of diploid
spermatogonial stem cells produce a large number of highly differentiated spermatozoa …

The germline stem cell niche unit in mammalian testes

JM Oatley, RL Brinster - Physiological reviews, 2012 - journals.physiology.org
This review addresses current understanding of the germline stem cell niche unit in
mammalian testes. Spermatogenesis is a classic model of tissue-specific stem cell function …

Spermatogenesis and cycle of the seminiferous epithelium

RA Hess, LR De Franca - Molecular mechanisms in spermatogenesis, 2009 - Springer
Spermatogenesis is a complex biological process of cellular transformation that produces
male haploid germ cells from diploid spermatogonial stem cells. This process has been …