Emerging roles of E2Fs in cancer: an exit from cell cycle control
Mutations of the retinoblastoma tumour suppressor gene (RB1) or components regulating
the RB pathway have been identified in almost every human malignancy. The E2F …
the RB pathway have been identified in almost every human malignancy. The E2F …
Strength in numbers: preventing rereplication via multiple mechanisms in eukaryotic cells
EE Arias, JC Walter - Genes & development, 2007 - genesdev.cshlp.org
In eukaryotic cells, prereplication complexes (pre-RCs) are assembled on chromatin in the
G1 phase, rendering origins of DNA replication competent to initiate DNA synthesis. When …
G1 phase, rendering origins of DNA replication competent to initiate DNA synthesis. When …
Oncogene-induced senescence is part of the tumorigenesis barrier imposed by DNA damage checkpoints
Recent studies have indicated the existence of tumorigenesis barriers that slow or inhibit the
progression of preneoplastic lesions to neoplasia. One such barrier involves DNA …
progression of preneoplastic lesions to neoplasia. One such barrier involves DNA …
Activation of the DNA damage checkpoint and genomic instability in human precancerous lesions
DNA damage checkpoint genes, such as p53, are frequently mutated in human cancer, but
the selective pressure for their inactivation remains elusive,,. We analysed a panel of human …
the selective pressure for their inactivation remains elusive,,. We analysed a panel of human …
Oncogene-induced senescence is a DNA damage response triggered by DNA hyper-replication
R Di Micco, M Fumagalli, A Cicalese, S Piccinin… - Nature, 2006 - nature.com
Early tumorigenesis is associated with the engagement of the DNA-damage checkpoint
response (DDR),. Cell proliferation and transformation induced by oncogene activation are …
response (DDR),. Cell proliferation and transformation induced by oncogene activation are …
Chronic p53-independent p21 expression causes genomic instability by deregulating replication licensing
The cyclin-dependent kinase inhibitor p21WAF1/CIP1 (p21) is a cell-cycle checkpoint
effector and inducer of senescence, regulated by p53. Yet, evidence suggests that p21 could …
effector and inducer of senescence, regulated by p53. Yet, evidence suggests that p21 could …
Machine learning and data mining frameworks for predicting drug response in cancer: An overview and a novel in silico screening process based on association rule …
A major challenge in cancer treatment is predicting the clinical response to anti-cancer
drugs on a personalized basis. The success of such a task largely depends on the ability to …
drugs on a personalized basis. The success of such a task largely depends on the ability to …
A recurrent chromosomal inversion suffices for driving escape from oncogene-induced senescence via subTAD reorganization
CP Zampetidis, P Galanos, A Angelopoulou, Y Zhu… - Molecular Cell, 2021 - cell.com
Oncogene-induced senescence (OIS) is an inherent and important tumor suppressor
mechanism. However, if not removed timely via immune surveillance, senescent cells also …
mechanism. However, if not removed timely via immune surveillance, senescent cells also …
INK4 proteins, a family of mammalian CDK inhibitors with novel biological functions
Abstract The cyclin D‐Cdk4‐6/INK4/Rb/E2F pathway plays a key role in controlling cell
growth by integrating multiple mitogenic and antimitogenic stimuli. The members of INK4 …
growth by integrating multiple mitogenic and antimitogenic stimuli. The members of INK4 …
Genomic stability and tumour suppression by the APC/C cofactor Cdh1
The anaphase promoting complex or cyclosome (APC/C) is a ubiquitin protein ligase that,
together with Cdc20 or Cdh1, targets cell-cycle proteins for degradation. APC/C–Cdh1 …
together with Cdc20 or Cdh1, targets cell-cycle proteins for degradation. APC/C–Cdh1 …