Malaria is a major cause of disease and death in tropical countries. A safe and effective
vaccine is essential to achieve significant and sustained reductions in malaria-related …

Abstract Interleukin (IL)‐18 is a pro‐inflammatory cytokine belonging to the IL‐1 family, first
identified for its interferon‐γ‐inducing properties. IL‐18 regulates both T helper (Th) 1 and …

Malaria is a mosquito-borne disease caused by parasites of the obligate intracellular
Apicomplexa phylum the most deadly of which, Plasmodium falciparum, prevails in Africa …

Throughout history malaria has proved to be a significant threat to human health. Between
300 and 500 million clinical cases occur each year worldwide, approximately 2 million of …

▪ Abstract Immune responses can cause severe disease, despite the role immunity plays in
defending against parasitism. Indeed, immunopathology is a remarkably common cause of …

Malaria causes an acute systemic human disease that bears many similarities, both
clinically and mechanistically, to those caused by bacteria, rickettsia, and viruses. Over the …

To determine the potential contribution of innate immune responses to the early
proinflammatory cytokine response to Plasmodium falciparum malaria, we have examined …

Understanding the regulation of immune responses is central for control of autoimmune and
infectious disease. In murine models of autoimmunity and chronic inflammatory disease …

Context: Inadequate vitamin D status is common within elderly populations and may be
implicated in the etiology of autoimmune disease and inflammation. Few studies have …

The outcome of malaria infection is determined, in part, by the balance of pro-inflammatory
and regulatory immune responses. Failure to develop an effective pro-inflammatory …