Members of the RTX family of protein toxins are functionally conserved among an
assortment of bacterial pathogens. By disrupting host cell integrity through their pore-forming …

Pore-forming proteins (PFPs) are a heterogeneous group of proteins that are expressed and
secreted by a wide range of organisms. PFPs are produced as soluble monomers that bind …

Permeabilization of the plasma membrane represents an important threat for any cell, since
it compromises its viability by disrupting cell homeostasis. Numerous pathogenic bacteria …

Pore-forming toxins (PFTs) form nanoscale pores across target membranes causing cell
death. The pore-forming cytolysins of the RTX (repeats in toxin) family belong to a steadily …

Alpha hemolysin (HlyA) is a hemolytic and cytotoxic protein secreted by uropathogenic
strains of E. coli. The role of glycophorins (GPs) as putative receptors for HlyA binding to red …

Alpha hemolysin of Escherichia coli (HlyA) is a pore-forming protein, which is a prototype of
the “R epeat in T ox ins”(RTX) family. It was demonstrated that HlyA–cholesterol interaction …

Aggregatibacter actinomycetemcomitans is a Gram‐negative bacterium associated with
localized aggressive periodontitis, as well as other systemic diseases. This organism …

α-Hemolysin (HlyA) is an exotoxin secreted by some pathogenic strains of Escherichia coli
that causes lysis of several mammalian cells, including erythrocytes of different species …

Uropathogenic strains of Escherichia coli deliver the toxin alpha-hemolysin (HlyA) to
optimize the host environment for the spread of infection. It was reported that at high …

Several toxins that act on animal cells present different, but specific, interactions with
cholesterol or sphingomyelin. In the present study we demonstrate that HlyA (α-haemolysin) …