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Isatin hybrids and their anti-tuberculosis activity
Tuberculosis (TB) is one of the most common and even fatal infectious diseases known to
mankind. Millions of new cases are reported every year over the world, and one-third of the …
mankind. Millions of new cases are reported every year over the world, and one-third of the …
[HTML][HTML] A mini review on isatin, an anticancer scaffold with potential activities against Neglected Tropical Diseases (Ntds)
Isatin, chemically an indole-1 H-2, 3-dione, is recognised as one of the most attractive
therapeutic fragments in drug design and development. The template has turned out to be …
therapeutic fragments in drug design and development. The template has turned out to be …
Indole derivatives as anti-tubercular agents: An overview on their synthesis and biological activities
Background: The indole framework is considered as one of the privileged structures in the
area of medicinal chemistry and drug discovery because compounds containing this …
area of medicinal chemistry and drug discovery because compounds containing this …
Transposon sequencing reveals metabolic pathways essential for Mycobacterium tuberculosis infection
AM Block, PC Wiegert, SB Namugenyi… - PLoS …, 2024 - journals.plos.org
New drugs are needed to shorten and simplify treatment of tuberculosis caused by
Mycobacterium tuberculosis. Metabolic pathways that M. tuberculosis requires for growth or …
Mycobacterium tuberculosis. Metabolic pathways that M. tuberculosis requires for growth or …
Isatin derivatives with potential antitubercular activities
D Jiang, GQ Wang, X Liu, Z Zhang… - Journal of …, 2018 - Wiley Online Library
Tuberculosis is a life‐threatening chronic infectious disease, which primarily affects the
lungs but can spread to other vital organs. The re‐emergence and wide spread of new …
lungs but can spread to other vital organs. The re‐emergence and wide spread of new …
Isatin conjugates as antibacterial agents: a brief review
Pathogenic bacteria, with their innate resistance to drugs, pose a constant threat to human
health and well-being and put a persistent strain on the health care system. Development of …
health and well-being and put a persistent strain on the health care system. Development of …
Mycobacterium tuberculosis chorismate mutase: A potential target for TB
M Khanapur, M Alvala, M Prabhakar, KS Kumar… - Bioorganic & medicinal …, 2017 - Elsevier
Mycobacterium tuberculosis chorismate mutase (Mtb CM) catalyzes the rearrangement of
chorismate to prephenate in the shikimate biosynthetic pathway to form the essential amino …
chorismate to prephenate in the shikimate biosynthetic pathway to form the essential amino …
Structure–activity relationship studies of indolin‐2‐one derivatives as vascular endothelial growth factor receptor inhibitors and anticancer agents
Angiogenesis is a requirement for the growth of cancer cells. The family of vascular
endothelial growth factor receptors (VEGFRs) is the main target in metastasis. Indolin‐2‐one …
endothelial growth factor receptors (VEGFRs) is the main target in metastasis. Indolin‐2‐one …
Repositioning of Isatin hybrids as novel anti-tubercular agents overcoming pre-existing antibiotics resistance
The widespread deaths of tuberculosis from many decades demands an urgent need for the
development of novel anti-tubercular scaffolds that are more potent and highly selective with …
development of novel anti-tubercular scaffolds that are more potent and highly selective with …
Combination of Hydrogen and Halogen Bonds in the Crystal Structures of 5-Halogeno-1H-isatin-3-oximes: Involvement of the Oxime Functionality in Halogen …
E Meier, W Seichter, M Mazik - Molecules, 2024 - mdpi.com
Various functional groups have been considered as acceptors for halogen bonds, but the
oxime functionality has received very little attention in this context. In this study, we focus on …
oxime functionality has received very little attention in this context. In this study, we focus on …