A gene fragment corresponding to the region of difference-1 (RD-1) of the Mycobacterium
tuberculosis genome, spanning open reading frames Rv3871 to Rv3879c, is missing in all …

Tuberculosis (TB) is a leading cause of morbidity and mortality worldwide. Global research
efforts to improve TB control are hindered by insufficient understanding of the role that …

The 6-kDa early secreted antigenic target ESAT-6 and the 10-kDa culture filtrate protein CFP-
10 of Mycobacterium tuberculosis are secreted by the ESX-1 system into the host cell and …

Immunizations with the conventional vaccines have failed to effectively inhibit the incidences
and further dissemination of the infections. To address it, we have implemented protein …

Mycobacterium tuberculosis infection generates pulmonary granulomas that consist of a
caseous, necrotic core surrounded by an ordered arrangement of macrophages, neutrophils …

Mycobacterium tuberculosis encodes five type VII secretion systems that are responsible for
exporting a number of proteins, including members of the Esx family, which have been …

Nanopore sensing of proteomic biomarkers lacks accuracy due to the ultralow abundance of
targets, a wide variety of interferents in clinical samples, and the mismatch between pore …

ABSTRACT ESAT-6 system 1 (ESX-1)-mediated secretion in Mycobacterium tuberculosis is
dependent on proteins encoded by the cotranscribed espA-espC-espD gene cluster. While …

EsxA (ESAT-6), an important virulence factor of Mycobacterium tuberculosis, plays an
essential role in phagosome rupture and bacterial cytosolic translocation within host …

Mycobacterium tuberculosis (Mtb) is a smart and successful pathogen since it can persist in
the intimidating environment of the host by taming and tuning the immune system. Mtb …