For our immune system to contain or eliminate malignant solid tumours, both myeloid and
lymphoid haematopoietic cells must not only extravasate from the bloodstream into the …

Melanoma, a skin cancer that develops from pigment cells, has been studied intensively,
particularly in terms of the immune response to tumours, and has been used as a model for …

Abstract 'Immune checkpoint blockade'for cancer describes the use of therapeutic antibodies
that disrupt negative immune regulatory checkpoints and unleash pre-existing antitumour …

Objective Use of the frailty index to measure an accumulation of deficits has been proven a
valuable method for identifying elderly people at risk for increased vulnerability, disease …

Resident memory B (BRM) cells develop and persist in the lungs of influenza-infected mice
and humans; however, their contribution to recall responses has not been defined. Here, we …

The kidney has a remarkable ability of repair after acute kidney injury (AKI). However, when
injury is severe or persistent, the repair is incomplete or maladaptive and may lead to …

The inflammatory chemokines CXCL9, CXCL10, and CXCL11 are predominantly induced
by interferon (IFN)-γ and share an exclusive chemokine receptor named CXC chemokine …

Sixteen years ago, the Nomenclature Committee of the International Union of Pharmacology
approved a system for naming human seven-transmembrane (7TM) G protein-coupled …

Mammalian hematopoietic stem cells (HSCs) colonize the bone marrow during late fetal
development, and this becomes the major site of hematopoiesis after birth. However, little is …

Surgical resection is an important avenue for cancer treatment, which, in most cases, can
effectively alleviate the patient symptoms. However, accumulating evidence has …