Physiology of the cerebellum

E D'Angelo - Handbook of clinical neurology, 2018 - Elsevier
The cerebellum is a central brain structure deeply integrated into major loops with the
cerebral cortex, brainstem, and spinal cord. The cerebellum shows a complex regional …

New clues for the role of cerebellum in schizophrenia and the associated cognitive impairment

P Faris, D Pischedda, F Palesi… - Frontiers in cellular …, 2024 - frontiersin.org
Schizophrenia (SZ) is a complex neuropsychiatric disorder associated with severe cognitive
dysfunction. Although research has mainly focused on forebrain abnormalities, emerging …

Consensus paper: decoding the contributions of the cerebellum as a time machine. From neurons to clinical applications

M Bareš, R Apps, L Avanzino, A Breska, E D'Angelo… - The Cerebellum, 2019 - Springer
Time perception is an essential element of conscious and subconscious experience,
coordinating our perception and interaction with the surrounding environment. In recent …

Modeling the cerebellar microcircuit: new strategies for a long-standing issue

E D'Angelo, A Antonietti, S Casali… - Frontiers in cellular …, 2016 - frontiersin.org
The cerebellar microcircuit has been the work bench for theoretical and computational
modeling since the beginning of neuroscientific research. The regular neural architecture of …

Activation of the CREB/c-Fos Pathway during Long-Term Synaptic Plasticity in the Cerebellum Granular Layer

D Gandolfi, S Cerri, J Mapelli, M Polimeni… - Frontiers in cellular …, 2017 - frontiersin.org
The induction of long-term potentiation and depression (LTP and LTD) is thought to trigger
gene expression and protein synthesis, leading to consolidation of synaptic and neuronal …

Model simulations unveil the structure-function-dynamics relationship of the cerebellar cortical microcircuit

R De Schepper, A Geminiani, S Masoli… - Communications …, 2022 - nature.com
The cerebellar network is renowned for its regular architecture that has inspired foundational
computational theories. However, the relationship between circuit structure, function and …

Reconstruction and simulation of a scaffold model of the cerebellar network

S Casali, E Marenzi, C Medini, C Casellato… - Frontiers in …, 2019 - frontiersin.org
Reconstructing neuronal microcircuits through computational models is fundamental to
simulate local neuronal dynamics. Here a scaffold model of the cerebellum has been …

Diverse neuron properties and complex network dynamics in the cerebellar cortical inhibitory circuit

F Prestori, L Mapelli, E D'Angelo - Frontiers in molecular neuroscience, 2019 - frontiersin.org
Neuronal inhibition can be defined as a spatiotemporal restriction or suppression of local
microcircuit activity. The importance of inhibition relies in its fundamental role in sha** …

Integrated plasticity at inhibitory and excitatory synapses in the cerebellar circuit

L Mapelli, M Pagani, JA Garrido… - Frontiers in cellular …, 2015 - frontiersin.org
The way long-term potentiation (LTP) and depression (LTD) are integrated within the
different synapses of brain neuronal circuits is poorly understood. In order to progress …

α6-Containing GABAA receptors: functional roles and therapeutic potentials

W Sieghart, LC Chiou, M Ernst, J Fabjan… - Pharmacological …, 2022 - Elsevier
GABA A receptors containing the α6 subunit are highly expressed in cerebellar granule cells
and less abundantly in many other neuronal and peripheral tissues. Here, we for the first …