It is increasingly accepted that early cognitive impairment in Alzheimer's disease results in
considerable part from synaptic dysfunction caused by the accumulation of a range of …

Iron is the most abundant transition metal within the brain, and is vital for a number of
cellular processes including neurotransmitter synthesis, myelination of neurons, and …

Abstract 2012 has been another year in which multiple large-scale clinical trials for
Alzheimer's disease (AD) have failed to meet their clinical endpoints. With the social and …

Alzheimer's disease (AD) is characterized by the presence of amyloid-β (Aβ)–containing
plaques, neurofibrillary tangles, and neuronal loss in the brain. Inflammatory changes …

A signature characteristic of Alzheimer's disease (AD) is aggregation of amyloid-beta (Aβ)
fibrils in the brain. Nevertheless, the links between Aβ and AD pathology remain …

Mitochondria are regarded as the metabolic centers of cells and are integral in many other
cell processes, including the immune response. Each mitochondrion contains numerous …

Significance: Mitochondria are fundamental to the life and proper functioning of cells. These
organelles play a key role in energy production, in maintaining homeostatic levels of second …

Although amyloid plaques and neurofibrillary pathology play important roles in Alzheimer
disease (AD), our understanding of AD is incomplete, and the contribution of microglia and …

Since the successful conquest of many acute, communicable (infectious) diseases through
the use of vaccines and antibiotics, the currently most prevalent diseases are chronic and …

Altered metabolism of biometals in the brain is a key feature of Alzheimer's disease, and
biometal interactions with amyloid-β are linked to amyloid plaque formation. Iron-rich …