PIWI-interacting RNAs: small RNAs with big functions

DM Ozata, I Gainetdinov, A Zoch, D O'Carroll… - Nature Reviews …, 2019 - nature.com
In animals, PIWI-interacting RNAs (piRNAs) of 21–35 nucleotides in length silence
transposable elements, regulate gene expression and fight viral infection. piRNAs guide …

Plant microRNAs: biogenesis, homeostasis, and degradation

J Wang, J Mei, G Ren - Frontiers in plant science, 2019 - frontiersin.org
MicroRNAs (miRNAs), a class of endogenous, tiny, non-coding RNAs, are master regulators
of gene expression among most eukaryotes. Intracellular miRNA abundance is regulated …

Regulation of microRNA biogenesis

M Ha, VN Kim - Nature reviews Molecular cell biology, 2014 - nature.com
MicroRNAs (miRNAs) are small non-coding RNAs that function as guide molecules in RNA
silencing. Targeting most protein-coding transcripts, miRNAs are involved in nearly all …

One loop to rule them all: the **-pong cycle and piRNA-guided silencing

B Czech, GJ Hannon - Trends in biochemical sciences, 2016 - cell.com
The PIWI-interacting RNA (piRNA) pathway is a conserved defense mechanism that protects
the genetic information of animal germ cells from the deleterious effects of molecular …

Diversifying microRNA sequence and function

SL Ameres, PD Zamore - Nature reviews Molecular cell biology, 2013 - nature.com
MicroRNAs (miRNAs) regulate the expression of most genes in animals, but we are only
now beginning to understand how they are generated, assembled into functional complexes …

[HTML][HTML] The long and short of microRNA

LA Yates, CJ Norbury, RJC Gilbert - Cell, 2013 - cell.com
MicroRNAs (miRNAs) are versatile regulators of gene expression in higher eukaryotes. In
order to silence many different mRNAs in a precise manner, miRNA stability and efficacy is …

Time-resolved small RNA sequencing unravels the molecular principles of microRNA homeostasis

B Reichholf, VA Herzog, N Fasching… - Molecular cell, 2019 - cell.com
Argonaute-bound microRNAs silence mRNA expression in a dynamic and regulated
manner to control organismal development, physiology, and disease. We employed …

The MicroRNA family gets wider: the IsomiRs classification and role

L Tomasello, R Distefano, G Nigita… - Frontiers in cell and …, 2021 - frontiersin.org
MicroRNAs (miRNAs or miRs) are the most characterized class of non-coding RNAs and are
engaged in many cellular processes, including cell differentiation, development, and …

IsomiRs–the overlooked repertoire in the dynamic microRNAome

CT Neilsen, GJ Goodall, CP Bracken - Trends in genetics, 2012 - cell.com
The development of deep sequencing has enabled the identification of novel microRNAs
(miRNAs), leading to a growing appreciation for the fact that individual miRNAs can be …

A single mechanism of biogenesis, initiated and directed by PIWI proteins, explains piRNA production in most animals

I Gainetdinov, C Colpan, A Arif, K Cecchini, PD Zamore - Molecular cell, 2018 - cell.com
In animals, PIWI-interacting RNAs (piRNAs) guide PIWI proteins to silence transposons and
regulate gene expression. The mechanisms for making piRNAs have been proposed to …