Environmental influences on the pace of brain development
Childhood socio-economic status (SES), a measure of the availability of material and social
resources, is one of the strongest predictors of lifelong well-being. Here we review evidence …
resources, is one of the strongest predictors of lifelong well-being. Here we review evidence …
Modulation of the hypothalamic-pituitary-adrenal axis by early life stress exposure
M Van Bodegom, JR Homberg… - Frontiers in cellular …, 2017 - frontiersin.org
Exposure to stress during critical periods in development can have severe long-term
consequences, increasing overall risk on psychopathology. One of the key stress response …
consequences, increasing overall risk on psychopathology. One of the key stress response …
Early life adversity shapes neural circuit function during sensitive postnatal developmental periods
Early life adversity (ELA) is a major risk factor for mental illness, but the neurobiological
mechanisms by which ELA increases the risk for future psychopathology are still poorly …
mechanisms by which ELA increases the risk for future psychopathology are still poorly …
Early life adversity shapes social subordination and cell type–specific transcriptomic patterning in the ventral hippocampus
Adverse events in early life can modulate the response to additional stressors later in life
and increase the risk of develo** psychiatric disorders. The underlying molecular …
and increase the risk of develo** psychiatric disorders. The underlying molecular …
Sex differences in hippocampal cognition and neurogenesis
S Yagi, LAM Galea - Neuropsychopharmacology, 2019 - nature.com
Sex differences are reported in hippocampal plasticity, cognition, and in a number of
disorders that target the integrity of the hippocampus. For example, meta-analyses reveal …
disorders that target the integrity of the hippocampus. For example, meta-analyses reveal …
Toward understanding how early-life stress reprograms cognitive and emotional brain networks
Y Chen, TZ Baram - Neuropsychopharmacology, 2016 - nature.com
Vulnerability to emotional disorders including depression derives from interactions between
genes and environment, especially during sensitive developmental periods. Adverse early …
genes and environment, especially during sensitive developmental periods. Adverse early …
Neurogenesis in aging and age-related neurodegenerative diseases
Adult neurogenesis, the process by which neurons are generated in certain areas of the
adult brain, declines in an age-dependent manner and is one potential target for extending …
adult brain, declines in an age-dependent manner and is one potential target for extending …
Chronic early life stress induced by limited bedding and nesting (LBN) material in rodents: critical considerations of methodology, outcomes and translational potential
The immediate and long-term effects of exposure to early life stress (ELS) have been
documented in humans and animal models. Even relatively brief periods of stress during the …
documented in humans and animal models. Even relatively brief periods of stress during the …
Animal models of major depression and their clinical implications
Major depressive disorder is a common, complex, and potentially life-threatening mental
disorder that imposes a severe social and economic burden worldwide. Over the years …
disorder that imposes a severe social and economic burden worldwide. Over the years …
Food for thought: how nutrition impacts cognition and emotion
SJ Spencer, A Korosi, S Layé, B Shukitt-Hale… - npj Science of …, 2017 - nature.com
More than one-third of American adults are obese and statistics are similar worldwide.
Caloric intake and diet composition have large and lasting effects on cognition and emotion …
Caloric intake and diet composition have large and lasting effects on cognition and emotion …