▪ Abstract The interferon system is the first line of defense against viral infection in mammals.
This system is designed to block the spread of virus infection in the body, sometimes at the …

This review describes the structure and function of the interferon (IFN)-inducible, double-
stranded RNA-activated protein kinase PKR. This protein kinase has been studied …

Protein kinase R (PKR) is an immune response protein that becomes activated by double-
stranded RNAs (dsRNAs). PKR overactivation is associated with degenerative diseases with …

Protein kinase RNA-activated (PKR) induces immune response by sensing viral double-
stranded RNAs (dsRNAs). However, growing evidence suggests that PKR can also be …

Hepatitis C virus (HCV) is the major cause of non-A non-B hepatitis and a leading cause of
liver dysfunction worldwide. While the current therapy for chronic HCV infection is parenteral …

PKR, a latent protein kinase, mediates the antiviral actions of interferon. It is also involved in
cellular signal transduction, apoptosis, growth regulation and differentiation. Although in …

Most multicellular organisms regulate developmental transitions by microRNAs, which are
generated by an enzyme, Dicer. Insects and fungi have two Dicer-like genes, and many …

As obligate intracellular parasites, viruses rely exclusively on the translational machinery of
the host cell for the synthesis of viral proteins. This relationship has imposed numerous …

Protein kinase PKR is an interferon‐induced enzyme that plays a key role in the control of
viral infections and cellular homeostasis. Compared with other known kinases, PKR is …

The interferon (IFN)-induced cellular antiviral response is the first line of defense against
viral infection within an animal host. In order to establish a productive infection, eukaryotic …