Signaling pathways and targeted therapies for psoriasis

J Guo, H Zhang, W Lin, L Lu, J Su… - Signal transduction and …, 2023 - nature.com
Psoriasis is a common, chronic, and inflammatory skin disease with a high burden on
individuals, health systems, and society worldwide. With the immunological pathologies and …

Emerging concepts of type I interferons in SLE pathogenesis and therapy

A Psarras, M Wittmann, EM Vital - Nature reviews Rheumatology, 2022 - nature.com
Type I interferons have been suspected for decades to have a crucial role in the
pathogenesis of systemic lupus erythematosus (SLE). Evidence has now overturned several …

Nonlesional lupus skin contributes to inflammatory education of myeloid cells and primes for cutaneous inflammation

AC Billi, F Ma, O Plazyo, M Gharaee-Kermani… - Science translational …, 2022 - science.org
Cutaneous lupus erythematosus (CLE) is a disfiguring and poorly understood condition
frequently associated with systemic lupus. Previous studies suggest that nonlesional …

[HTML][HTML] The relapse of psoriasis: mechanisms and mysteries

D Tian, Y Lai - JID Innovations, 2022 - Elsevier
Over the past decades, tremendous success in the treatment of psoriasis has been achieved
using biologics, such as neutralizing antibodies against TNF/TNFR, IL-23, and IL-17A/IL …

Immunopathogenesis of systemic lupus erythematosus: an update

L Arnaud, F Chasset, T Martin - Autoimmunity Reviews, 2024 - Elsevier
Systemic lupus erythematosus (SLE) is a chronic systemic autoimmune disease
characterized by dysregulated immune responses leading to widespread inflammation and …

Innate and adaptive immunity during SARS-CoV-2 infection: biomolecular cellular markers and mechanisms

B Brown, V Ojha, I Fricke, SA Al-Sheboul, C Imarogbe… - Vaccines, 2023 - mdpi.com
The coronavirus 2019 (COVID-19) pandemic was caused by a positive sense single-
stranded RNA (ssRNA) severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) …

Low-level inflammation, immunity, and brain-gut axis in IBS: unraveling the complex relationships

Y Yuan, X Wang, S Huang, H Wang, G Shen - Gut Microbes, 2023 - Taylor & Francis
Irritable bowel syndrome is a common functional gastrointestinal disorder, and it has been
shown that the etiology of irritable bowel syndrome is a multifactorial complex of …

Mitochondrial and metabolic dysfunction of peripheral immune cells in multiple sclerosis

PF Wang, F Jiang, QM Zeng, WF Yin, YZ Hu… - Journal of …, 2024 - Springer
Multiple sclerosis (MS) is a chronic autoimmune disorder characterized by the infiltration of
inflammatory cells and demyelination of nerves. Mitochondrial dysfunction has been …

Neutrophils in cancer and potential therapeutic strategies using neutrophil-derived exosomes

A Dutta, S Bhagat, S Paul, JP Katz, D Sengupta… - Vaccines, 2023 - mdpi.com
Neutrophils are the most abundant immune cells and make up about 70% of white blood
cells in human blood and play a critical role as the first line of defense in the innate immune …

[HTML][HTML] Plasmacytoid dendritic cells: A dendritic cell in disguise

RA Hornero, J Idoyaga - Molecular immunology, 2023 - Elsevier
Since their discovery, the identity of plasmacytoid dendritic cells (pDCs) has been at the
center of a continuous dispute in the field, and their classification as dendritic cells (DCs) …