New drugs with new mechanisms of action are urgently required to tackle the global
tuberculosis epidemic. Following the FDA-approval of the ATP synthase inhibitor …

Abstract The Pathogen Box is a 400‐strong collection of drug‐like compounds, selected for
their potential against several of the world's most important neglected tropical diseases …

Inspired by quinine and its analogues, we designed, synthesized, and evaluated two series
of quinoline small molecular compounds (a and 2a) and six series of quinoline derivatives …

Herein a series of 4-aminoquinolines were synthesized in an attempt to optimize and study
the structural features related to LABIO-17 biological activity, a Mycobacterium tuberculosis …

In this work, a series of 2-(trifluoromethyl) quinolin-4-amine derivatives were designed and
synthesized through structural optimization strategy as a microtubule-targeted agents …

Using a classical molecular simplification approach, a series of 36 quinolines were
synthesized and evaluated as in vitro inhibitors of Mycobacterium tuberculosis (M …

Tuberculosis (TB), a disease caused mainly by the Mycobacterium tuberculosis (Mtb), is
according to the World Health Organization (WHO) the infectious disease responsible for the …

Recently, ATP synthase inhibitor Bedaquiline was approved for the treatment of multi-drug
resistant tuberculosis emphasizing the importance of oxidative phosphorylation for the …

During our studies into preparing analogues of pyrazolopyrimidine as ATP synthesis
inhibitors of Mycobacterium tuberculosis, a regiospecific condensation reaction between …

Using cycloalkyl and electron-donating groups to decrease the carbonyl electrophilicity, a
novel series of 2-(quinoline-4-yloxy) acetamides was synthesized and evaluated as in vitro …