The cGAS–STING pathway is an evolutionarily conserved immune signaling pathway critical
for microbial defense. Unlike other innate immune pathways that largely rely on stationary …

The immune system has evolved to protect the host from the pathogens and allergens
surrounding their environment. The immune system develops in such a way to recognize …

Zoonoses are infectious diseases transmitted from animals to humans. Bats have been
suggested to harbour more zoonotic viruses than any other mammalian order. Infections in …

Stimulator of interferon genes (STING) is an endoplasmic-reticulum resident protein, playing
essential roles in immune responses against microbial infections. However, over-activation …

The basic function of the immune system is the protection of the host against infections,
along with the preservation of the individual antigenic identity. The process of self-tolerance …

Immune sentinel cells initiate immune responses to pathogens and tissue injury and are
capable of producing highly stimulus-specific responses. Insight into the mechanisms …

Cannabis (Cannabis sativa) is a widely used drug in the United States and the frequency of
cannabis use is particularly high among people living with HIV (PLWH). One key component …

Necroptotic cell death is mediated by a super-molecular complex called necrosome which
consists of receptor-interacting protein kinase 1 and 3 (RIPK1, RIPK3) and mixed-lineage …

Kaposi's sarcoma-associated herpesvirus (KSHV) establishes persistent infection in the host
by encoding a vast network of proteins that aid immune evasion. One of these targeted …

Gammaherpesviruses are ubiquitous pathogens that establish lifelong infections in the vast
majority of adults worldwide. Importantly, these viruses are associated with numerous …