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Atopic dermatitis: an expanding therapeutic pipeline for a complex disease
T Bieber - Nature reviews Drug discovery, 2022 - nature.com
Atopic dermatitis (AD) is a common chronic inflammatory skin disease with a complex
pathophysiology that underlies a wide spectrum of clinical phenotypes. AD remains …
pathophysiology that underlies a wide spectrum of clinical phenotypes. AD remains …
Novel insights into atopic dermatitis
Recent research into the pathophysiology and treatment of atopic dermatitis (AD) has shown
notable progress. An increasing number of aspects of the immune system are being …
notable progress. An increasing number of aspects of the immune system are being …
Two phase 3 trials of lebrikizumab for moderate-to-severe atopic dermatitis
Background Lebrikizumab, a high-affinity IgG4 monoclonal antibody targeting interleukin-13,
prevents the formation of the interleukin-4Rα–interleukin-13Rα1 heterodimer receptor …
prevents the formation of the interleukin-4Rα–interleukin-13Rα1 heterodimer receptor …
JAK inhibitors in the treatment of atopic dermatitis
R Chovatiya, AS Paller - Journal of Allergy and Clinical Immunology, 2021 - Elsevier
Atopic dermatitis (AD) is a chronic inflammatory skin disorder associated with heterogenous
presentation and often immense patient burden. Safe, targeted treatment options are …
presentation and often immense patient burden. Safe, targeted treatment options are …
Rhinitis associated with asthma is distinct from rhinitis alone: the ARIA‐MeDALL hypothesis
Asthma, rhinitis, and atopic dermatitis (AD) are interrelated clinical phenotypes that partly
overlap in the human interactome. The concept of “one‐airway‐one‐disease,” coined over …
overlap in the human interactome. The concept of “one‐airway‐one‐disease,” coined over …
Dupilumab-associated head and neck dermatitis shows a pronounced type 22 immune signature mediated by oligoclonally expanded T cells
C Bangert, N Alkon, S Chennareddy… - Nature …, 2024 - nature.com
Dupilumab, an IL4R-blocking antibody, has shown clinical efficacy for atopic dermatitis (AD)
treatment. In addition to conjunctivitis/blepharitis, the de novo appearance of head/neck …
treatment. In addition to conjunctivitis/blepharitis, the de novo appearance of head/neck …
[HTML][HTML] Revisiting the roles of filaggrin in atopic dermatitis
V Moosbrugger-Martinz, C Leprince… - International Journal of …, 2022 - mdpi.com
The discovery in 2006 that loss-of-function mutations in the filaggrin gene (FLG) cause
ichthyosis vulgaris and can predispose to atopic dermatitis (AD) galvanized the dermatology …
ichthyosis vulgaris and can predispose to atopic dermatitis (AD) galvanized the dermatology …
[HTML][HTML] Neuroimmune communication regulating pruritus in atopic dermatitis
Atopic dermatitis (AD) is a common, chronic-relapsing inflammatory skin disease with
significant disease burden. Genetic and environmental trigger factors contribute to AD …
significant disease burden. Genetic and environmental trigger factors contribute to AD …
The translational revolution in atopic dermatitis: the paradigm shift from pathogenesis to treatment
P Facheris, J Jeffery, E Del Duca… - Cellular & molecular …, 2023 - nature.com
Atopic dermatitis (AD) is the most common inflammatory skin disease, and it is considered a
complex and heterogeneous condition. Different phenotypes of AD, defined according to the …
complex and heterogeneous condition. Different phenotypes of AD, defined according to the …
[HTML][HTML] Multiple roles for cytokines in atopic dermatitis: from pathogenic mediators to endotype-specific biomarkers to therapeutic targets
Atopic dermatitis (AD) is one of the most common chronic inflammatory skin diseases, which
generally presents with intense itching and recurrent eczematous lesions. AD affects up to …
generally presents with intense itching and recurrent eczematous lesions. AD affects up to …