Atopic dermatitis: an expanding therapeutic pipeline for a complex disease

T Bieber - Nature reviews Drug discovery, 2022 - nature.com
Atopic dermatitis (AD) is a common chronic inflammatory skin disease with a complex
pathophysiology that underlies a wide spectrum of clinical phenotypes. AD remains …

Novel insights into atopic dermatitis

CF Schuler IV, AC Billi, E Maverakis, LC Tsoi… - Journal of Allergy and …, 2023 - Elsevier
Recent research into the pathophysiology and treatment of atopic dermatitis (AD) has shown
notable progress. An increasing number of aspects of the immune system are being …

Two phase 3 trials of lebrikizumab for moderate-to-severe atopic dermatitis

JI Silverberg, E Guttman-Yassky, D Thaçi… - … England Journal of …, 2023 - Mass Medical Soc
Background Lebrikizumab, a high-affinity IgG4 monoclonal antibody targeting interleukin-13,
prevents the formation of the interleukin-4Rα–interleukin-13Rα1 heterodimer receptor …

JAK inhibitors in the treatment of atopic dermatitis

R Chovatiya, AS Paller - Journal of Allergy and Clinical Immunology, 2021 - Elsevier
Atopic dermatitis (AD) is a chronic inflammatory skin disorder associated with heterogenous
presentation and often immense patient burden. Safe, targeted treatment options are …

Rhinitis associated with asthma is distinct from rhinitis alone: the ARIA‐MeDALL hypothesis

J Bousquet, E Melén, T Haahtela, GH Koppelman… - Allergy, 2023 - Wiley Online Library
Asthma, rhinitis, and atopic dermatitis (AD) are interrelated clinical phenotypes that partly
overlap in the human interactome. The concept of “one‐airway‐one‐disease,” coined over …

Dupilumab-associated head and neck dermatitis shows a pronounced type 22 immune signature mediated by oligoclonally expanded T cells

C Bangert, N Alkon, S Chennareddy… - Nature …, 2024 - nature.com
Dupilumab, an IL4R-blocking antibody, has shown clinical efficacy for atopic dermatitis (AD)
treatment. In addition to conjunctivitis/blepharitis, the de novo appearance of head/neck …

[HTML][HTML] Revisiting the roles of filaggrin in atopic dermatitis

V Moosbrugger-Martinz, C Leprince… - International Journal of …, 2022 - mdpi.com
The discovery in 2006 that loss-of-function mutations in the filaggrin gene (FLG) cause
ichthyosis vulgaris and can predispose to atopic dermatitis (AD) galvanized the dermatology …

[HTML][HTML] Neuroimmune communication regulating pruritus in atopic dermatitis

M Steinhoff, F Ahmad, A Pandey, A Datsi… - Journal of Allergy and …, 2022 - Elsevier
Atopic dermatitis (AD) is a common, chronic-relapsing inflammatory skin disease with
significant disease burden. Genetic and environmental trigger factors contribute to AD …

The translational revolution in atopic dermatitis: the paradigm shift from pathogenesis to treatment

P Facheris, J Jeffery, E Del Duca… - Cellular & molecular …, 2023 - nature.com
Atopic dermatitis (AD) is the most common inflammatory skin disease, and it is considered a
complex and heterogeneous condition. Different phenotypes of AD, defined according to the …

[HTML][HTML] Multiple roles for cytokines in atopic dermatitis: from pathogenic mediators to endotype-specific biomarkers to therapeutic targets

L Fania, G Moretta, F Antonelli, E Scala… - International Journal of …, 2022 - mdpi.com
Atopic dermatitis (AD) is one of the most common chronic inflammatory skin diseases, which
generally presents with intense itching and recurrent eczematous lesions. AD affects up to …