Endocytosis is the major regulator of signaling from receptor tyrosine kinases (RTKs). The
canonical model of RTK endocytosis involves rapid internalization of an RTK activated by …

The major process that regulates the amplitude and kinetics of signal transduction by
tyrosine kinase receptors is endocytic removal of active ligand–receptor complexes from the …

In several growth factor receptors, the intracellular juxtamembrane (JM) region participates
in autoinhibitory interactions that must be disrupted for tyrosine kinase activation. Using …

Binding of extracellular ligands to epidermal growth factor receptors (EGFR) activate signal
transduction pathways associated with cell proliferation, and these events are inhibited by …

A ligand-insensitive form of the human epidermal growth factor receptor (EGFR) was
enriched by Ca2+-dependent calmodulin-affinity chromatography purification. The basic …

In this review, we first describe the mechanisms by which the epidermal growth factor
receptor generates a Ca2+ signal and, subsequently, we compile the available experimental …

Tyrosine phosphorylation of the β2 subunit of clathrin adaptor complex AP-2 was detected in
three types of cells treated with epidermal growth factor (EGF). The tyrosine phosphorylation …

The protein encoded by the Menkes disease gene (MNK) is localised to the Golgi apparatus
and cycles between the trans-Golgi network and the plasma membrane in cultured cells on …

One early response to epidermal growth factor receptor (EGFR) activation is an increase in
intracellular calcium. We have used surface plasmon resonance (SPR) to study real-time …

The cytokine interleukin-10 (IL-10) is an important regulator of immune cell function,
proliferation, and survival. The IL-10 receptor (IL-10R) consists of two subunits, IL-10R1 and …