Corticosteroid feedback inhibits the brain-hypothalamo-pituitary units of the adrenocortical
system. Naturally occurring corticosteroids may have their primary actions in vivo at brain …

IN THE 25 yrs after the first demonstration of CRF in hypothalamic tissue (1, 2), research on
CRF progressed along two major lines of experimentation. In the context of a functional …

The hypothalamo‐pituitary‐adrenal axis (HPA) is responsible for stimulation of adrenal
corticosteroids in response to stress. Negative feedback control by corticosteroids limits …

The hypothalamic-pituitary-adrenal system shows an overall diminished responsiveness
throughout ontogeny. Thus, during this period, the sensitivity of the adrenal gland to ACTH is …

Rapid, non-transcriptionally mediated, effects of glucocorticoids affect many behaviors as
well as inhibition of function in the hypothalamo–pituitary–adrenal axis. In this short review, it …

Purpose. The present study investigates fast negative feedback actions of corticosterone
(corticosteroid type I/type II receptor agonist) and RU 28362 (corticosteroid type II receptor …

Fifty patients participated in this controlled double-blind study. The results showed that,
when compared with a placebo, injection of the steroid (dexamethasone, 4 mg) significantly …

As an initial step in investigating the role of steroid hormones in lymphangiomyomatosis, the
cytosolic receptors for steroid hormones were determined by a dextran charcoal method …

Pharmacodynamic models for “directly suppressive” effects of methylprednisolone are
based on the premise that receptor interactions of steroids are followed by immediate …

Background: Despite enormous progress in the medical treatment of inflammatory bowel
diseases (IBD), corticosteroids still represent the most effective drugs in the management of …