Rheumatoid arthritis (RA) is characterized by inflammation and destruction of bone and
cartilage in affected joints. Autoimmune responses lead to increased osteoclastic bone …

Bone is an active tissue, being constantly renewed in healthy individuals with participation of
the immune system to a large extent. Any imbalance between the processes of bone …

Gut microbial dysbiosis is associated with the development of autoimmune disease, but the
mechanisms by which microbial dysbiosis affects the transition from asymptomatic …

The immune and skeletal systems share a variety of molecules, including cytokines,
chemokines, hormones, receptors, and transcription factors. Bone cells interact with immune …

Osteoporosis is a skeletal system disease characterized by low bone mass and altered bone
microarchitecture, with an increased risk of fractures. Classical theories hold that …

The identification of stem cells and growth factors as well as the development of biomaterials
hold great promise for regenerative medicine applications. However, the therapeutic efficacy …

The role of immune system in various bone pathologies, such as osteoporosis, osteoarthritis,
and rheumatoid arthritis is now well established. This had led to the emergence of a modern …

The mechanisms underlying bone development, repair and regeneration are reliant on the
interplay and communication between osteoclasts and other surrounding cells. Osteoclasts …

Bone erosion is a central feature of rheumatoid arthritis and is associated with disease
severity and poor functional outcome. Erosion of periarticular cortical bone, the typical …

The term osteoimmunology was coined many years ago to describe the research field that
deals with the cross-regulation between bone cells and the immune system. As a matter of …