Synthesis, biological activity and POM/DFT/docking analyses of annulated pyrano [2, 3-d] pyrimidine derivatives: Identification of antibacterial and antitumor …

AR Bhat, RS Dongre, FA Almalki, M Berredjem… - Bioorganic …, 2021 - Elsevier
Abstract New annulated pyrano [2, 3-d] pyrimidine derivatives were synthesized with
hydroxyl, methoxy, bromine, nitrile and nitro substituents on its skeleton. The correlated …

New tetrahydropyrimidine-1, 2, 3-triazole clubbed compounds: Antitubercular activity and Thymidine Monophosphate Kinase (TMPKmt) inhibition

MS El-Shoukrofy, A Atta, S Fahmy, D Sriram… - Bioorganic …, 2023 - Elsevier
Two series of new tetrahydropyrimidine (THPM)-1, 2, 3-triazole clubbed compounds were
designed, synthesized and screened for their antitubercular (anti-TB) activity against M …

Discovery of pyrimidine-tethered benzothiazole derivatives as novel anti-tubercular agents towards multi- and extensively drug resistant Mycobacterium tuberculosis

LR Hemeda, MA El Hassab… - Journal of Enzyme …, 2023 - Taylor & Francis
In this study, new benzothiazole–pyrimidine hybrids (5a–c, 6, 7a–f, and 8–15) were
designed and synthesised. Two different functionalities on the pyrimidine moiety of lead …

Synthesis of new pyrimidine derivatives and their antiproliferative activity against selected human cancer cell lines

SM Awad, OA Fathalla, J Wietrzyk, M Milczarek… - Research on Chemical …, 2015 - Springer
Amino-2-thiouracil (1) was condensed with benzenesulfonyl chloride and p-toluenesulfonyl
chloride in presence of pyridine as an acid binder to give sulfonamides 2a, b, which could …

[PDF][PDF] Mg (OMe) 2 as a versatile catalyst for one-pot synthesis of 6-aryl-5-cyano-2-(oxo/thio) uracil derivatives and their antimicrobial evaluations

YLN Murthy, RMR Saviri, AR Parimi… - Organic …, 2013 - acgpubs.org
A series of substituted 6-aryl 5-cyano 2-uracil and 6-aryl 5-cyano 2-thiouracils (1a-1l) were
achieved by the reaction of various aldehydes, ureas, thioureas and ethylcyanoacetate …

Synthesis and biological value of thiouracils and fused thiouracils (a review)

M Sayed, N Ahmed - Journal of Advanced Pharmacy Research, 2017 - journals.ekb.eg
A literature survey revealed that the thiouracil derivatives and their condensed heterocycles
have occupied a marked position as synthon for various biologically active compounds …

[PDF][PDF] Effect of new synthesized compounds of 2-Thiouracil Sulfonamide Derivatives against colon and liver carcinoma cells “In Vitro Study

SM HASSAN, ANA AL-JAF… - International Journal …, 2020 - researchgate.net
Many studies have been focusedon 2-Thiouracil derivatives as an anti-cancer therapy. The
target compounds were prepared to be tested on colon and liver carcinoma cells and …

Bioassay and bioactivity of polymer as carrier for some active compounds such as anticancer drugs

FM Helaly, AI Khalaf, DEE Nashar, HFA Hamid… - Research on Chemical …, 2014 - Springer
The present work deals with the development of a new slow release polymeric material,
based on maize starch/cellulose acetate blend polymerized with acrylic acid monomer by …

Inhibitory effect of some new uracil and thiouracil derivatives on cercarial penetration enzymes

OA Fathalla, ME Haiba, MM Anwar… - Research on Chemical …, 2013 - Springer
Abstract Some uracil-and thiouracil-5-sulfonohydrazide derivatives have been synthesized
to be evaluated as antischistosomal agents. N-[2-(1, 5-Dimethyl-3-oxo-2-phenylpyrazolin-4 …

[CITATION][C] FM Helaly, AI Khalaf, DE El. Nashar, HF Abdel Hamid &

AM Soliman - Res Chem Intermed, 2014