Despite extensive research and improvements in understanding colorectal cancer (CRC), its
metastatic form continues to pose a substantial challenge, primarily owing to limited …

Experimental evidence from the past years highlights a key role for the intestinal microbiota
in inflammatory and malignant gastrointestinal diseases. Diet exhibits a strong impact on …

The microbiota has been shown to promote intestinal tumourigenesis, but a possible anti-
tumourigenic effect has also been postulated. Here, we demonstrate that changes in the …

The intestinal epithelium is a rapidly renewing cellular compartment. This constant
regeneration is a hallmark of intestinal homeostasis and requires a tightly regulated balance …

Allogeneic haematopoietic stem cell transplantation (allo-HSCT) is considered to be the
strongest curative immunotherapy for various malignancies (primarily, but not limited to …

Cancer is a major public health problem worldwide. Gastrointestinal cancers account for
approximately one-third of the total global cancer incidence and mortality. Historically, the …

Gastrointestinal microbiome, containing at least 100 trillion bacteria, resides in the mucosal
surface of human intestine. Recent studies show that perturbations in the microbiota may …

The human microbiome confers benefits or disease susceptibility to the human body through
multiple pathways. Disruption of the symbiotic balance of the human microbiome is …

PGAM5 is a mitochondrial serine/threonine phosphatase that regulates multiple metabolic
pathways and contributes to tumorigenesis in a poorly understood manner. We show here …

The gut microbiota has been hailed as an accessory organ, with functions critical to the host
including dietary metabolic activities and assistance in the development of a proper …