Oligodendrocyte precursor cells (OPCs) account for 5% of the resident parenchymal central
nervous system glial cells. OPCs are not only a back-up for the loss of oligodendrocytes that …

Oligodendrocytes are the myelinating glia of the central nervous system. Myelination of
axons allows rapid saltatory conduction of nerve impulses and contributes to axonal …

Myelination of axons in the nervous system of vertebrates enables fast, saltatory impulse
propagation, one of the best-understood concepts in neurophysiology. However, it took a …

Leukodystrophies are genetically determined disorders characterized by the selective
involvement of the central nervous system white matter. Onset may be at any age, from …

Mounting evidence suggests that neuronal activity influences myelination, potentially
allowing for experience-driven modulation of neural circuitry. The degree to which neuronal …

Infants born prematurely are at high risk to develop white matter injury (WMI), due to
exposure to hypoxic and/or inflammatory insults. Such perinatal insults negatively impact the …

Despite a lack of recent progress in the treatment of schizophrenia, our understanding of its
genetic and environmental causes has considerably improved, and their relationship to …

Experience sculpts brain structure and function. Activity-dependent modulation of the
myelinated infrastructure of the nervous system has emerged as a dimension of adaptive …

Vertebrate myelination is an evolutionary advancement essential for motor, sensory, and
higher-order cognitive function. CNS myelin, a multilamellar differentiation of the …

Advances in neuroimaging have enabled greater understanding of the progression of
cerebral degenerative processes associated with ageing‐related dementias. Leukoaraiosis …