The Crumbs complex has prominent roles in the control of apical cell polarity, in the coupling
of cell density sensing to downstream cell signaling pathways, and in regulating junctional …

MicroRNAs (miRNAs) are short nucleotides sequences that regulate the expression of
genes in different eukaryotic cell types. A tremendous amount of knowledge on miRNAs has …

Retinopathy of prematurity (ROP) is a disorder of the develo** retina of preterm infants.
ROP can lead to blindness because of abnormal angiogenesis that is the result of …

Retinal Müller glia can serve as a source for regeneration of damaged retinal neurons in
fish, birds and mammals. However, the proliferation rate of Müller glia has been reported to …

Nerve growth factor (NGF) is the best characterized neurotrophin, and it is known to play an
important role in ocular homeostasis. Here, we demonstrated the expression of NGF …

In nonphagocytic cells, Rac1 is a component of NADPH oxidase that produces reactive
oxygen species [Ushio-Fukai M (2006) Sci STKE 2006: re8]. Rac1 is expressed abundantly …

Drosophila melanogaster Crumbs (Crb) and its mammalian orthologues (CRB1–3) share
evolutionarily conserved but poorly defined roles in regulating epithelial polarity and, in …

Purpose Light-induced photoreceptor cell degeneration and disease progression in age-
related macular degeneration (AMD) involve oxidative stress and visual cell loss, which can …

Accruing evidence indicates that connexin (Cx) channels in the gap junctions (GJ) are
involved in neurodegeneration after injury. However, studies using KO animal models …

Photoreceptor cell death can cause progressive and irreversible visual impairments. Still,
effective therapies on retinal neuroprotection are not available. Hypoxia-inducible factors …