Identifying miRNAs, targets and functions
Abstract microRNAs (miRNAs) are small endogenous non-coding RNAs that function as the
universal specificity factors in post-transcriptional gene silencing. Discovering miRNAs …
universal specificity factors in post-transcriptional gene silencing. Discovering miRNAs …
[HTML][HTML] MicroRNAs: synthesis, mechanism, function, and recent clinical trials
MicroRNAs (miRNAs) are a class of small, endogenous RNAs of 21–25 nucleotides (nts) in
length. They play an important regulatory role in animals and plants by targeting specific …
length. They play an important regulatory role in animals and plants by targeting specific …
Prediction of on-target and off-target activity of CRISPR–Cas13d guide RNAs using deep learning
Transcriptome engineering applications in living cells with RNA-targeting CRISPR effectors
depend on accurate prediction of on-target activity and off-target avoidance. Here we design …
depend on accurate prediction of on-target activity and off-target avoidance. Here we design …
FlyAtlas 2: a new version of the Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
Abstract FlyAtlas 2 (www. flyatlas2. org) is part successor, part complement to the FlyAtlas
database and web application for studying the expression of the genes of Drosophila …
database and web application for studying the expression of the genes of Drosophila …
Analysis of 13 cell types reveals evidence for the expression of numerous novel primate-and tissue-specific microRNAs
E Londin, P Loher, AG Telonis… - Proceedings of the …, 2015 - National Acad Sciences
Two decades after the discovery of the first animal microRNA (miRNA), the number of
miRNAs in animal genomes remains a vexing question. Here, we report findings from …
miRNAs in animal genomes remains a vexing question. Here, we report findings from …
The functions of animal microRNAs
V Ambros - Nature, 2004 - nature.com
MicroRNAs (miRNAs) are small RNAs that regulate the expression of complementary
messenger RNAs. Hundreds of miRNA genes have been found in diverse animals, and …
messenger RNAs. Hundreds of miRNA genes have been found in diverse animals, and …
[HTML][HTML] MicroRNAs: genomics, biogenesis, mechanism, and function
DP Bartel - cell, 2004 - cell.com
MicroRNAs (miRNAs) are endogenous∼ 22 nt RNAs that can play important regulatory
roles in animals and plants by targeting mRNAs for cleavage or translational repression …
roles in animals and plants by targeting mRNAs for cleavage or translational repression …
Oncomirs—microRNAs with a role in cancer
A Esquela-Kerscher, FJ Slack - Nature reviews cancer, 2006 - nature.com
MicroRNAs (miRNAs) are an abundant class of small non-protein-coding RNAs that function
as negative gene regulators. They regulate diverse biological processes, and bioinformatic …
as negative gene regulators. They regulate diverse biological processes, and bioinformatic …
Biogenesis of small RNAs in animals
VN Kim, J Han, MC Siomi - Nature reviews Molecular cell biology, 2009 - nature.com
Small RNAs of 20–30 nucleotides can target both chromatin and transcripts, and thereby
keep both the genome and the transcriptome under extensive surveillance. Recent progress …
keep both the genome and the transcriptome under extensive surveillance. Recent progress …
[HTML][HTML] Prediction of mammalian microRNA targets
BP Lewis, I Shih, MW Jones-Rhoades, DP Bartel… - Cell, 2003 - cell.com
MicroRNAs (miRNAs) can play important gene regulatory roles in nematodes, insects, and
plants by basepairing to mRNAs to specify posttranscriptional repression of these …
plants by basepairing to mRNAs to specify posttranscriptional repression of these …