Abstract The coronavirus disease 2019 (COVID-19) has been a global pandemic for more
than 2 years and it still impacts our daily lifestyle and quality in unprecedented ways. A …

Mitochondrial disorders are among the most frequent inborn errors of metabolism, their
primary cause being the dysfunction of the oxidative phosphorylation system (OXPHOS) …

Modifications on mRNA offer the potential of regulating mRNA fate post-transcriptionally.
Recent studies suggested the widespread presence of N 1-methyladenosine (m1A), which …

Mitochondria are ubiquitous intracellular organelles found in almost all eukaryotes and
involved in various aspects of cellular life, with a primary role in energy production. The …

The unorthodox genetics of the mtDNA is providing new perspectives on the etiology of the
common “complex” diseases. The maternally inherited mtDNA codes for essential energy …

Defects of mitochondrial metabolism cause a wide range of human diseases that include
examples from all medical subspecialties. This review updates the topic of mitochondrial …

The human mitochondrial genome involves over 1,000 genes, dispersed across the
maternally inherited mitochondrial DNA (mtDNA) and the biparentally inherited nuclear DNA …

Mitochondrial dysfunction has been linked to a wide range of degenerative and metabolic
diseases, cancer, and aging. All these clinical manifestations arise from the central role of …

Mitochondria are increasingly recognized as central players in the life and death of cells and
especially of neurons. The energy-dependence of retinal ganglion cells (RGC) and their …

Leber hereditary optic neuropathy (LHON) is a mitochondrial genetic disease that
preferentially causes blindness in young adult males, affecting about 1 in 25 000 of the …