Autophagy in age-related macular degeneration

K Kaarniranta, J Blasiak, P Liton, M Boulton… - Autophagy, 2023 - Taylor & Francis
Age-related macular degeneration (AMD) is the leading cause of visual impairment in the
aging population with limited understanding of its pathogenesis and a lack of effective …

[HTML][HTML] Mechanisms of mitochondrial dysfunction and their impact on age-related macular degeneration

K Kaarniranta, H Uusitalo, J Blasiak… - Progress in retinal and …, 2020 - Elsevier
Oxidative stress-induced damage to the retinal pigment epithelium (RPE) is considered to
be a key factor in age-related macular degeneration (AMD) pathology. RPE cells are …

Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1

DJ Klionsky, AK Abdel-Aziz, S Abdelfatah, M Abdellatif… - autophagy, 2021 - Taylor & Francis
In 2008, we published the first set of guidelines for standardizing research in autophagy.
Since then, this topic has received increasing attention, and many scientists have entered …

Oxidative stress and antioxidants in age-related macular degeneration

N Kushwah, K Bora, M Maurya, MC Pavlovich, J Chen - Antioxidants, 2023 - mdpi.com
Oxidative stress plays a crucial role in aging-related eye diseases, including age-related
macular degeneration (AMD), cataracts, and glaucoma. With age, antioxidant reparative …

Cellular senescence in the aging retina and developments of senotherapies for age-related macular degeneration

KS Lee, S Lin, DA Copland, AD Dick, J Liu - Journal of Neuroinflammation, 2021 - Springer
Age-related macular degeneration (AMD), a degenerative disease in the central macula
area of the neuroretina and the supporting retinal pigment epithelium, is the most common …

The AKT2/SIRT5/TFEB pathway as a potential therapeutic target in non-neovascular AMD

S Ghosh, R Sharma, S Bammidi, V Koontz… - Nature …, 2024 - nature.com
Non-neovascular or dry age-related macular degeneration (AMD) is a multi-factorial disease
with degeneration of the aging retinal-pigmented epithelium (RPE). Lysosomes play a …

Age-related macular degeneration: role of oxidative stress and blood vessels

Y Ruan, S Jiang, A Gericke - International journal of molecular sciences, 2021 - mdpi.com
Age-related macular degeneration (AMD) is a common irreversible ocular disease
characterized by vision impairment among older people. Many risk factors are related to …

Retina in a dish: Cell cultures, retinal explants and animal models for common diseases of the retina

S Schnichels, F Paquet-Durand, M Löscher… - Progress in retinal and …, 2021 - Elsevier
For many retinal diseases, including age-related macular degeneration (AMD), glaucoma,
and diabetic retinopathy (DR), the exact pathogenesis is still unclear. Moreover, the currently …

Role of mitochondrial DNA damage in ROS-mediated pathogenesis of age-related macular degeneration (AMD)

K Kaarniranta, E Pawlowska, J Szczepanska… - International journal of …, 2019 - mdpi.com
Age-related macular degeneration (AMD) is a complex eye disease that affects millions of
people worldwide and is the main reason for legal blindness and vision loss in the elderly in …

Oxidative stress-involved mitophagy of retinal pigment epithelium and retinal degenerative diseases

SM Zhang, B Fan, YL Li, ZY Zuo, GY Li - Cellular and Molecular …, 2023 - Springer
The retinal pigment epithelium (RPE) is a highly specialized and polarized epithelial cell
layer that plays an important role in sustaining the structural and functional integrity of …