Chemical genetics is the study of gene-product function in a cellular or organismal context
using exogenous ligands. In this approach, small molecules that bind directly to proteins are …

Transforming growth factor‐beta (TGF‐β) is an important growth inhibitor of epithelial cells,
and insensitivity to this cytokine results in uncontrolled cell proliferation and can contribute to …

Combinatorial libraries of synthetic and natural products are an important source of
molecular information for the interrogation of biological targets. Methods for the intracellular …

Aptamers are nucleic acid ligands which are isolated from combinatorial oligonucleotide
libraries by in vitro selection. They exhibit highly complex and sophisticated molecular …

In Saccharomyces cerevisiae, mothers and daughters have distinct fates. We show that
Cbk1 kinase and its interacting protein Mob2 regulate this asymmetry by inducing daughter …

Members of the NDR (nuclear Dbf2-related) protein-kinase family are essential components
of pathways that control important cellular processes, such as morphological changes …

By using genome information to create tools for perturbing gene function, it is now possible
to undertake systematic genome-wide functional screens that examine the contribution of …

Protein‐protein interactions play a central role in numerous processes in the cell and are
one of the main fields of functional proteomics. This review highlights the methods of …

The completion of the human genome sequence and the development of new techniques,
which allow the visualisation of comprehensive gene expression patterns, has led to the …

Kidney research is entering an era of 'big data'and molecular omics data can provide
comprehensive insights into the molecular footprints of cells. In contrast to transcriptomics …