Cell-based therapies are being developed for various neurodegenerative diseases that
affect the central nervous system (CNS). Concomitantly, the roles of individual cell types in …

Although the core concept of remyelination—based on the activation, migration, proliferation
and differentiation of CNS progenitors—has not changed over the past 20 years, our …

Human pluripotent stem cells have emerged as a promising in vitro model system for
studying the brain. Two-dimensional and three-dimensional cell culture paradigms have …

Human pluripotent stem cells (hPSCs) provide a model to study early neural development,
model pathological processes, and develop therapeutics. The generation of functionally …

Radiotherapy remains a mainstay of cancer treatment, being used in roughly 50% of
patients. The precision with which the radiation dose can be delivered is rapidly improving …

Rapid and efficient protocols to generate oligodendrocytes (OL) from human induced
pluripotent stem cells (iPSC) are currently lacking, but may be a key technology to …

Oligodendrocytes produce myelin, an insulating sheath required for the saltatory conduction
of electrical impulses along axons. Oligodendrocyte loss results in demyelination, which …

Injury to the central nervous system (CNS) results in oligodendrocyte cell death and
progressive demyelination. Demyelinated axons undergo considerable physiological …

Cerebral small vessel disease (CSVD) represents a diverse cluster of cerebrovascular
diseases primarily affecting small arteries, capillaries, arterioles and venules. The diagnosis …

The myelination of axons by oligodendrocytes is a highly complex cell-to-cell interaction.
Oligodendrocytes and axons have a reciprocal signaling relationship in which …