Quantifying brain microstructure with diffusion MRI: Theory and parameter estimation

DS Novikov, E Fieremans, SN Jespersen… - NMR in …, 2019 - Wiley Online Library
We review, systematize and discuss models of diffusion in neuronal tissue, by putting them
into an overarching physical context of coarse‐graining over an increasing diffusion length …

Dendritic spines: Revisiting the physiological role

SB Chidambaram, AG Rathipriya, SR Bolla… - Progress in Neuro …, 2019 - Elsevier
Dendritic spines are small, thin, specialized protrusions from neuronal dendrites, primarily
localized in the excitatory synapses. Sophisticated imaging techniques revealed that …

Reactive astrocytes function as phagocytes after brain ischemia via ABCA1-mediated pathway

YM Morizawa, Y Hirayama, N Ohno, S Shibata… - Nature …, 2017 - nature.com
Astrocytes become reactive following various brain insults; however, the functions of reactive
astrocytes are poorly understood. Here, we show that reactive astrocytes function as …

Novel stroke therapeutics: unraveling stroke pathophysiology and its impact on clinical treatments

PM George, GK Steinberg - Neuron, 2015 - cell.com
Stroke remains a leading cause of death and disability in the world. Over the past few
decades our understanding of the pathophysiology of stroke has increased, but greater …

Recovery after brain injury: mechanisms and principles

RJ Nudo - Frontiers in human neuroscience, 2013 - frontiersin.org
The past 20 years have represented an important period in the development of principles
underlying neuroplasticity, especially as they apply to recovery from neurological injury. It is …

Janus-faced microglia: beneficial and detrimental consequences of microglial phagocytosis

A Sierra, O Abiega, A Shahraz… - Frontiers in cellular …, 2013 - frontiersin.org
Microglia are the resident brain macrophages and they have been traditionally studied as
orchestrators of the brain inflammatory response during infections and disease. In addition …

Plasticity during stroke recovery: from synapse to behaviour

TH Murphy, D Corbett - Nature reviews neuroscience, 2009 - nature.com
Reductions in blood flow to the brain of sufficient duration and extent lead to stroke, which
results in damage to neuronal networks and the impairment of sensation, movement or …

Resting microglia directly monitor the functional state of synapses in vivo and determine the fate of ischemic terminals

H Wake, AJ Moorhouse, S **no, S Kohsaka… - Journal of …, 2009 - jneurosci.org
Recent studies have identified the important contribution of glial cells to the plasticity of
neuronal circuits. Resting microglia, the primary immune effector cells in the brain …

Revealing mesoscopic structural universality with diffusion

DS Novikov, JH Jensen, JA Helpern… - Proceedings of the …, 2014 - pnas.org
Measuring molecular diffusion is widely used for characterizing materials and living
organisms noninvasively. This characterization relies on relations between macroscopic …

A review of exercise-induced neuroplasticity in ischemic stroke: pathology and mechanisms

Y **ng, Y Bai - Molecular Neurobiology, 2020 - Springer
After ischemic stroke, survivors experience motor dysfunction and deterioration of memory
and cognition. These symptoms are associated with the disruption of normal neuronal …