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Drug-induced liver injury: recent advances in diagnosis and risk assessment
GA Kullak-Ublick, RJ Andrade, M Merz, P End… - Gut, 2017 - gut.bmj.com
Idiosyncratic drug-induced liver injury (IDILI) is a rare but potentially severe adverse drug
reaction that should be considered in patients who develop laboratory criteria for liver injury …
reaction that should be considered in patients who develop laboratory criteria for liver injury …
Oxidative stress in drug-induced liver injury (DILI): from mechanisms to biomarkers for use in clinical practice
M Villanueva-Paz, L Morán, N López-Alcántara… - Antioxidants, 2021 - mdpi.com
Idiosyncratic drug-induced liver injury (DILI) is a type of hepatic injury caused by an
uncommon drug adverse reaction that can develop to conditions spanning from …
uncommon drug adverse reaction that can develop to conditions spanning from …
Drug-induced hypersensitivity syndrome (DIHS)/drug reaction with eosinophilia and systemic symptoms (DRESS): clinical features and pathogenesis
N Hama, R Abe, A Gibson, EJ Phillips - The Journal of Allergy and Clinical …, 2022 - Elsevier
Drug-induced hypersensitivity syndrome/drug reaction with eosinophilia and systemic
symptoms (DIHS/DRESS) is one example of a severe delayed T-cell–mediated adverse …
symptoms (DIHS/DRESS) is one example of a severe delayed T-cell–mediated adverse …
Managing the challenge of drug-induced liver injury: a roadmap for the development and deployment of preclinical predictive models
RJ Weaver, EA Blomme, AE Chadwick… - Nature Reviews Drug …, 2020 - nature.com
Drug-induced liver injury (DILI) is a patient-specific, temporal, multifactorial
pathophysiological process that cannot yet be recapitulated in a single in vitro model …
pathophysiological process that cannot yet be recapitulated in a single in vitro model …
Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in …
This review encompasses the most important advances in liver functions and hepatotoxicity
and analyzes which mechanisms can be studied in vitro. In a complex architecture of nested …
and analyzes which mechanisms can be studied in vitro. In a complex architecture of nested …
[HTML][HTML] Drug-induced liver injury: cascade of events leading to cell death, apoptosis or necrosis
Drug-induced liver injury (DILI) can broadly be divided into predictable and dose dependent
such as acetaminophen (APAP) and unpredictable or idiosyncratic DILI (IDILI). Liver injury …
such as acetaminophen (APAP) and unpredictable or idiosyncratic DILI (IDILI). Liver injury …
CSH guidelines for the diagnosis and treatment of drug-induced liver injury
Drug-induced liver injury (DILI) is an important clinical problem, which has received more
attention in recent decades. It can be induced by small chemical molecules, biological …
attention in recent decades. It can be induced by small chemical molecules, biological …
Case definition and phenotype standardization in drug‐induced liver injury
Drug‐induced liver injury (DILI) is the most frequent reason cited for the withdrawal of
approved drugs from the market and accounts for up to 15% of the cases of acute liver …
approved drugs from the market and accounts for up to 15% of the cases of acute liver …
[PDF][PDF] HLA‐B*35:01 Allele Is a Potential Biomarker for Predicting Polygonum multiflorum–Induced Liver Injury in Humans
C Li, T Rao, X Chen, Z Zou, A Wei, J Tang… - …, 2019 - Wiley Online Library
Polygonum multiflorum (PM) is a well‐known Chinese herbal medicine that has been
reported to induce inflammation‐associated idiosyncratic liver injury. This study aimed to …
reported to induce inflammation‐associated idiosyncratic liver injury. This study aimed to …
Genome-wide association study identifies susceptibility loci for IgA nephropathy
We carried out a genome-wide association study of IgA nephropathy, a major cause of
kidney failure worldwide. We studied 1,194 cases and 902 controls of Chinese Han …
kidney failure worldwide. We studied 1,194 cases and 902 controls of Chinese Han …