Drug-induced liver injury: recent advances in diagnosis and risk assessment

GA Kullak-Ublick, RJ Andrade, M Merz, P End… - Gut, 2017 - gut.bmj.com
Idiosyncratic drug-induced liver injury (IDILI) is a rare but potentially severe adverse drug
reaction that should be considered in patients who develop laboratory criteria for liver injury …

Oxidative stress in drug-induced liver injury (DILI): from mechanisms to biomarkers for use in clinical practice

M Villanueva-Paz, L Morán, N López-Alcántara… - Antioxidants, 2021 - mdpi.com
Idiosyncratic drug-induced liver injury (DILI) is a type of hepatic injury caused by an
uncommon drug adverse reaction that can develop to conditions spanning from …

Drug-induced hypersensitivity syndrome (DIHS)/drug reaction with eosinophilia and systemic symptoms (DRESS): clinical features and pathogenesis

N Hama, R Abe, A Gibson, EJ Phillips - The Journal of Allergy and Clinical …, 2022 - Elsevier
Drug-induced hypersensitivity syndrome/drug reaction with eosinophilia and systemic
symptoms (DIHS/DRESS) is one example of a severe delayed T-cell–mediated adverse …

Managing the challenge of drug-induced liver injury: a roadmap for the development and deployment of preclinical predictive models

RJ Weaver, EA Blomme, AE Chadwick… - Nature Reviews Drug …, 2020 - nature.com
Drug-induced liver injury (DILI) is a patient-specific, temporal, multifactorial
pathophysiological process that cannot yet be recapitulated in a single in vitro model …

Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in …

P Godoy, NJ Hewitt, U Albrecht, ME Andersen… - Archives of …, 2013 - Springer
This review encompasses the most important advances in liver functions and hepatotoxicity
and analyzes which mechanisms can be studied in vitro. In a complex architecture of nested …

[HTML][HTML] Drug-induced liver injury: cascade of events leading to cell death, apoptosis or necrosis

A Iorga, L Dara, N Kaplowitz - International journal of molecular sciences, 2017 - mdpi.com
Drug-induced liver injury (DILI) can broadly be divided into predictable and dose dependent
such as acetaminophen (APAP) and unpredictable or idiosyncratic DILI (IDILI). Liver injury …

CSH guidelines for the diagnosis and treatment of drug-induced liver injury

Y Yu, Y Mao, C Chen, J Chen, J Chen, W Cong… - Hepatology …, 2017 - Springer
Drug-induced liver injury (DILI) is an important clinical problem, which has received more
attention in recent decades. It can be induced by small chemical molecules, biological …

Case definition and phenotype standardization in drug‐induced liver injury

GP Aithal, PB Watkins, RJ Andrade… - Clinical …, 2011 - Wiley Online Library
Drug‐induced liver injury (DILI) is the most frequent reason cited for the withdrawal of
approved drugs from the market and accounts for up to 15% of the cases of acute liver …

[PDF][PDF] HLA‐B*35:01 Allele Is a Potential Biomarker for Predicting Polygonum multiflorum–Induced Liver Injury in Humans

C Li, T Rao, X Chen, Z Zou, A Wei, J Tang… - …, 2019 - Wiley Online Library
Polygonum multiflorum (PM) is a well‐known Chinese herbal medicine that has been
reported to induce inflammation‐associated idiosyncratic liver injury. This study aimed to …

Genome-wide association study identifies susceptibility loci for IgA nephropathy

AG Gharavi, K Kiryluk, M Choi, Y Li, P Hou, J **e… - Nature …, 2011 - nature.com
We carried out a genome-wide association study of IgA nephropathy, a major cause of
kidney failure worldwide. We studied 1,194 cases and 902 controls of Chinese Han …