Advanced methods for natural products discovery: bioactivity screening, dereplication, metabolomics profiling, genomic sequencing, databases and informatic tools …
Natural Products (NP) are essential for the discovery of novel drugs and products for
numerous biotechnological applications. The NP discovery process is expensive and time …
numerous biotechnological applications. The NP discovery process is expensive and time …
The case against antibiotics and for anti-virulence therapeutics
JA Hotinger, ST Morris, AE May - Microorganisms, 2021 - mdpi.com
Although antibiotics have been indispensable in the advancement of modern medicine,
there are downsides to their use. Growing resistance to broad-spectrum antibiotics is …
there are downsides to their use. Growing resistance to broad-spectrum antibiotics is …
Systems and synthetic biology to elucidate secondary metabolite biosynthetic gene clusters encoded in Streptomyces genomes
Covering: 2010 to 2020 Over the last few decades, Streptomyces have been extensively
investigated for their ability to produce diverse bioactive secondary metabolites. Recent …
investigated for their ability to produce diverse bioactive secondary metabolites. Recent …
Comparative genomics of Rothia species reveals diversity in novel biosynthetic gene clusters and ecological adaptation to different eukaryotic hosts and host niches
Rothia species are understudied members of the phylum Actinobacteria and prevalent
colonizers of the human and animal upper respiratory tract and oral cavity. The oral cavity …
colonizers of the human and animal upper respiratory tract and oral cavity. The oral cavity …
Insight into unprecedented diversity of cyanopeptides in eutrophic ponds using an ms/ms networking approach
Man-made shallow fishponds in the Czech Republic have been facing high eutrophication
since the 1950s. Anthropogenic eutrophication and feeding of fish have strongly affected the …
since the 1950s. Anthropogenic eutrophication and feeding of fish have strongly affected the …
Screening and Identification of a Streptomyces Strain with Quorum-Sensing Inhibitory Activity and Effect of the Crude Extracts on Virulence Factors of Pseudomonas …
Z Zhang, Y Sun, Y Yi, X Bai, L Zhu, J Zhu, M Gu, Y Zhu… - Microorganisms, 2023 - mdpi.com
Quorum-sensing (QS) is involved in numerous physiological processes in bacteria, such as
biofilm formation, sporulation, and virulence formation. Therefore, the search for new …
biofilm formation, sporulation, and virulence formation. Therefore, the search for new …
Mining Indonesian microbial biodiversity for novel natural compounds by a combined genome mining and molecular networking approach
Indonesia is one of the most biodiverse countries in the world and a promising resource for
novel natural compound producers. Actinomycetes produce about two thirds of all clinically …
novel natural compound producers. Actinomycetes produce about two thirds of all clinically …
Metabologenomics approach to the discovery of novel compounds from Streptomyces sp. GMR22 as anti-SARS-CoV-2 drugs
COVID-19 is spreading rapidly yet there is no clinically proven drug available now. Soil-
derived Streptomyces sp. GMR22 has a large genome size (11.4 Mbp) and a huge BGCs …
derived Streptomyces sp. GMR22 has a large genome size (11.4 Mbp) and a huge BGCs …
Taxogenomic and Comparative Genomic Analysis of the Genus Saccharomonospora Focused on the Identification of Biosynthetic Clusters PKS and NRPS
Actinobacteria are prokaryotes with a large biotechnological interest due to their ability to
produce secondary metabolites, produced by two main biosynthetic gene clusters (BGCs) …
produce secondary metabolites, produced by two main biosynthetic gene clusters (BGCs) …
Biosynthetic Potential of Streptomyces Rationalizes Genome-Based Bioprospecting
Streptomyces are the most prolific source of structurally diverse microbial natural products.
Advancing genome-based analysis reveals the previously unseen potential of Streptomyces …
Advancing genome-based analysis reveals the previously unseen potential of Streptomyces …