Extensive development of inhaled and oral glucocorticoids has resulted in highly potent
molecules that have been optimized to target activity to the lung and minimize systemic …

Glucocorticoids (GCs) regulate cell fate by altering gene expression via the glucocorticoid
receptor (GR). Ligand-bound GR can activate the transcription of genes carrying the specific …

Glucocorticoids (GCs) have been widely used for decades as a first-line treatment for
inflammatory and autoimmune diseases. However, their use is often hampered by the onset …

The basal transcriptional activity of nuclear receptors (NRs) is regulated by interactions with
additional comodulator proteins (coactivator/corepressor). Here, we describe a new …

Objective To establish linkage and replicate the association of macrophage migration
inhibitory factor (MIF) with juvenile idiopathic arthritis (JIA). Methods Three hundred twenty …

Glucocorticoids inhibit inflammation by acting through the glucocorticoid receptor (GR) and
powerfully repressing NF-κB function. Ligand binding to the C-terminal of GR promotes the …

Glucocorticoid hormones are essential for life in vertebrates. They act through the
glucocorticoid receptor (GR), which is expressed in virtually all cells of the human body. Yet …

Glucocorticoid hormones exert a wide spectrum of metabolic and immunological effects.
They function through the glucocorticoid receptor, a member of the nuclear receptor …

Many glucocorticoid (Gc) actions are of rapid onset and therefore require acute regulation of
intracellular signaling cascades. Integration of diverse extracellular signals requires cross …

BACKGROUND: The glucocorticoid receptor (GR) is able to participate in regulation of
transcription by a variety of mechanisms, one of which involves DNA binding and …