Extracellular vesicles: mediators of intercellular communication in tissue injury and disease

G Berumen Sánchez, KE Bunn, HH Pua… - Cell Communication and …, 2021 - Springer
Intercellular communication is a critical process that ensures cooperation between distinct
cell types and maintains homeostasis. EVs, which were initially described as cellular debris …

Extracellular vesicles in cancer—implications for future improvements in cancer care

R Xu, A Rai, M Chen, W Suwakulsiri… - Nature reviews Clinical …, 2018 - nature.com
The sustained growth, invasion, and metastasis of cancer cells depend upon bidirectional
cell–cell communication within complex tissue environments. Such communication …

Extracellular vesicles in liquid biopsies as biomarkers for solid tumors

B Irmer, S Chandrabalan, L Maas, A Bleckmann… - Cancers, 2023 - mdpi.com
Simple Summary During the past decade, liquid biopsy-related publications have increased
exponentially, demonstrating the great potential of screening body fluids for diagnosis …

Physical principles of membrane shape regulation by the glycocalyx

CR Shurer, JCH Kuo, LDM Roberts, JG Gandhi… - Cell, 2019 - cell.com
Cells bend their plasma membranes into highly curved forms to interact with the local
environment, but how shape generation is regulated is not fully resolved. Here, we report a …

The biology of extracellular microvesicles

AE Sedgwick, C D'Souza‐Schorey - Traffic, 2018 - Wiley Online Library
The study of extracellular vesicles (EVs) is a rapidly evolving field, owing in large part to
recent advances in the realization of their significant contributions to normal physiology and …

The role of extracellular vesicles in the hallmarks of cancer and drug resistance

CPR Xavier, HR Caires, MAG Barbosa, R Bergantim… - Cells, 2020 - mdpi.com
Extracellular vesicles (EVs) mediate intercellular signaling and communication, allowing the
intercellular exchange of proteins, lipids, and genetic material. Their recognized role in the …

Extracellular vesicles as a novel source of biomarkers in liquid biopsies for monitoring cancer progression and drug resistance

MH Vasconcelos, HR Caires, A Ābols… - Drug Resistance …, 2019 - Elsevier
Cancer-derived extracellular vesicles (EVs) have been detected in the bloodstream and
other biofluids of cancer patients. They carry various tumor-derived molecules such as …

Glycosylation of cancer extracellular vesicles: capture strategies, functional roles and potential clinical applications

ÁM Martins, CC Ramos, D Freitas, CA Reis - Cells, 2021 - mdpi.com
Glycans are major constituents of extracellular vesicles (EVs). Alterations in the
glycosylation pathway are a common feature of cancer cells, which gives rise to de novo or …

Magneto-mediated electrochemical sensor for simultaneous analysis of breast cancer exosomal proteins

Y An, R Li, F Zhang, P He - Analytical chemistry, 2020 - ACS Publications
Breast cancer is a heterogeneous disease, and it lacks special tumor markers. Exosomes,
new noninvasive biomarkers, with the proteins on the exosome surface show potential for …

Extracellular vesicles as emerging targets in cancer: Recent development from bench to bedside

K Wu, F **ng, SY Wu, K Watabe - … et Biophysica Acta (BBA)-Reviews on …, 2017 - Elsevier
Extracellular vesicles (EVs) have emerged as important players of cancer initiation and
progression through cell-cell communication. They have been recognized as critical …