Microemulsions are thermodynamically stable, transparent, colloidal drug carrier system
extensively used by the scientists for effective drug delivery across the skin. It is a …

Tacrolimus, a novel macrocyclic lactone with potent immunosuppressive properties, is
currently available as an intravenous formulation and as a capsule for oral use, although …

The aim of this study was to establish a new preparation method for solid dispersion
formulation (SDF) of tacrolimus, a poorly water-soluble drug, without dichloromethane …

In recent years, many new immunosuppressive drugs have been discovered and developed
for clinical use in transplantation. This review focuses on those drugs (leflunomide …

The macrolide immunosuppressant FK506 (tacrolimus) is a powerful and selective anti-T-
lymphocyte agent that was discovered in 1984. This agent, isolated from the fungus …

Progress in raparnycin (RP~ I) research has been rapid and is poised to accelerate even
more dramatically. An Investigational New Drug application (11\'1)) for phase I trials ofRPM …

The enhancing effects of cyclodextrins (CyDs) on the solubility, the dissolution rate, and the
bioavailability of tacrolimus after oral administration to rats were examined and compared …

The objective of present investigation was to formulate self-microemulsifying drug delivery
systems (SMEDDS) of tacrolimus (FK 506), a poorly water soluble immunosuppressant that …

We have investigated the oral bioavailability of granules of albendazole, a drug used for
treating echinococcosis in man, prepared by the solid dispersion technique. Rapid …

OBJECTIVE: To review the clinical pharmacology, pharmacokinetics, adverse effects,
therapeutic uses, and current status of tacrolimus. DATA SOURCES: Data from scientific …