CD28 costimulation: from mechanism to therapy
Ligation of the CD28 receptor on T cells provides a critical second signal alongside T cell
receptor (TCR) ligation for naive T cell activation. Here, we discuss the expression, structure …
receptor (TCR) ligation for naive T cell activation. Here, we discuss the expression, structure …
An enigmatic tail of CD28 signaling
JS Boomer, JM Green - Cold Spring Harbor perspectives …, 2010 - cshperspectives.cshlp.org
CD28 costimulation regulates a wide range of cellular processes, from proliferation and
survival to promoting the differentiation of specialized T-cell subsets. Since first being …
survival to promoting the differentiation of specialized T-cell subsets. Since first being …
Mammalian target of rapamycin protein complex 2 regulates differentiation of Th1 and Th2 cell subsets via distinct signaling pathways
Many functions of the mammalian target of rapamycin (mTOR) complex 1 (mTORC1) have
been defined, but relatively little is known about the biology of an alternative mTOR complex …
been defined, but relatively little is known about the biology of an alternative mTOR complex …
CD28 costimulation of develo** thymocytes induces Foxp3 expression and regulatory T cell differentiation independently of interleukin 2
Efficient generation of regulatory T cells (Treg cells) in the thymus requires CD28
costimulation, but it is not known why. Here, molecular map** of CD28 costimulation …
costimulation, but it is not known why. Here, molecular map** of CD28 costimulation …
Spatiotemporal regulation of T cell costimulation by TCR-CD28 microclusters and protein kinase C θ translocation
T Yokosuka, W Kobayashi, K Sakata-Sogawa… - Immunity, 2008 - cell.com
T cell activation is mediated by microclusters (MCs) containing T cell receptors (TCRs),
kinases, and adaptors. Although TCR MCs translocate to form a central supramolecular …
kinases, and adaptors. Although TCR MCs translocate to form a central supramolecular …
CD28 induces immunostimulatory signals in dendritic cells via CD80 and CD86
Bidirectional signaling along the B7–CTLA-4 coreceptor pathway enables reciprocal
conditioning of T cells and dendritic cells. Although T cells can instruct dendritic cells to …
conditioning of T cells and dendritic cells. Although T cells can instruct dendritic cells to …
Signaling pathways in Th2 development
KA Mowen, LH Glimcher - Immunological reviews, 2004 - Wiley Online Library
In order for an immune response to be successful, it must be of the appropriate type and
magnitude. Intracellular residing pathogens require a cell‐mediated immune response …
magnitude. Intracellular residing pathogens require a cell‐mediated immune response …
The p110δ isoform of phosphoinositide 3-kinase controls clonal expansion and differentiation of Th cells
The role of PI3K in T cell activation and costimulation has been controversial. We previously
reported that a kinase-inactivating mutation (D910A) in the p110δ isoform of PI3K results in …
reported that a kinase-inactivating mutation (D910A) in the p110δ isoform of PI3K results in …
Peeking Into the Black Box of T Cell Receptor Signaling
A Weiss - Annual Review of Immunology, 2023 - annualreviews.org
I have spent more than the last 40 years at the University of California, San Francisco
(UCSF), studying T cell receptor (TCR) signaling. I was blessed with supportive mentors, an …
(UCSF), studying T cell receptor (TCR) signaling. I was blessed with supportive mentors, an …
Interleukin-2 enhances CD4+ T cell memory by promoting the generation of IL-7Rα–expressing cells
H Dooms, K Wolslegel, P Lin, AK Abbas - The Journal of experimental …, 2007 - rupress.org
The common γ chain cytokines interleukin (IL)-2 and IL-7 are important regulators of T cell
homeostasis. Although IL-2 is implicated in the acute phase of the T cell response, IL-7 is …
homeostasis. Although IL-2 is implicated in the acute phase of the T cell response, IL-7 is …