Brain-derived neurotrophic factor (BDNF) is a member of the neurotrophin family of growth
factors that plays a crucial role in the development of the nervous system while supporting …

Multi-pathway approaches for the treatment of complex polygenic disorders are emerging as
alternatives to classical monotarget therapies and microRNAs are of particular interest in …

The emerging complexity of the transcriptional landscape poses great challenges to our
conventional preconceptions of how the genome regulates brain function and dysfunction …

Late-onset Alzheimer's disease (LOAD) is a high-occurrence neurological disorder but the
difficulty in identifying precise and early biomarkers has complicated the understanding of …

A general hallmark of neurological diseases is the loss of redox homeostasis that triggers
oxidative damages to biomolecules compromising neuronal function. Under physiological …

A number of neurodegenerative diseases are accompanied by disordered smell function.
The degree of dysfunction can vary among different diseases, such that olfactory testing can …

Alzheimer's disease (AD) is a large and growing public health problem. It is characterized by
the accumulation of amyloid-β peptides and abnormally phosphorylated tau proteins that are …

Epigenomic modifications of the brain-derived neurotrophic factor (BDNF) gene have been
postulated to underlie the pathogenesis of neurodevelopmental, psychiatric, and …

Alzheimer's disease (AD) is the most common age-related, progressive neurodegenerative
disease. It is characterized by memory loss and cognitive decline and responsible for most …

The need for practical biomarkers for early diagnosis of Alzheimer's disease (AD) remains
largely unmet. Here we investigated the use of blood-based microRNAs as prognostic …