A comprehensive account on recent progress in pharmacological activities of benzimidazole derivatives
Nowadays, nitrogenous heterocyclic molecules have attracted a great deal of interest
among medicinal chemists. Among these potential heterocyclic drugs, benzimidazole …
among medicinal chemists. Among these potential heterocyclic drugs, benzimidazole …
Synthesis and molecular docking studies of potent α-glucosidase inhibitors based on biscoumarin skeleton
In our effort directed toward the discovery of new anti-diabetic agent for the treatment of
diabetes, a library of biscoumarin derivative 1–18 was synthesized and evaluated for α …
diabetes, a library of biscoumarin derivative 1–18 was synthesized and evaluated for α …
Synthesis and Antifungal Activity of 2-Chloromethyl-1H-benzimidazole Derivatives against Phytopathogenic Fungi in Vitro
A series of 35 benzimidazole derivatives were synthesized from 2-chloromethyl-1 H-
benzimidazole in good yields. Their structures were characterized by 1H and 13C NMR and …
benzimidazole in good yields. Their structures were characterized by 1H and 13C NMR and …
Synthesis, molecular docking and α-glucosidase inhibition of 5-aryl-2-(6′-nitrobenzofuran-2′-yl)-1, 3, 4-oxadiazoles
Abstract Twenty derivatives of 5-aryl-2-(6′-nitrobenzofuran-2′-yl)-1, 3, 4-oxadiazoles (1–
20) were synthesized and evaluated for their α-glucosidase inhibitory activities. Compounds …
20) were synthesized and evaluated for their α-glucosidase inhibitory activities. Compounds …
2-Aryl benzimidazoles: synthesis, in vitro α-amylase inhibitory activity, and molecular docking study
Despite of many diverse biological activities exhibited by benzimidazole scaffold, it is rarely
explored for the α-amylase inhibitory activity. For that purpose, 2-aryl benzimidazole …
explored for the α-amylase inhibitory activity. For that purpose, 2-aryl benzimidazole …
Preferential inhibition of Wnt/β-catenin signaling by novel benzimidazole compounds in triple-negative breast cancer
Wnt/β-catenin signaling is upregulated in triple-negative breast cancer (TNBC) compared to
other breast cancer subtypes and normal tissues. Current Wnt/β-catenin inhibitors, such as …
other breast cancer subtypes and normal tissues. Current Wnt/β-catenin inhibitors, such as …
Synthesis of benzimidazole derivatives as potent β-glucuronidase inhibitors
Abstract Twenty five 4, 6-dichlorobenzimidazole derivatives (1–25) have been synthesized
and evaluated against β-glucuronidase inhibitory activity. The compounds which actively …
and evaluated against β-glucuronidase inhibitory activity. The compounds which actively …
Synthesis of novel benzohydrazone–oxadiazole hybrids as β-glucuronidase inhibitors and molecular modeling studies
A series of compounds consisting of 25 novel oxadiazole–benzohydrazone hybrids (6–30)
were synthesized through a five-step reaction sequence and evaluated for their β …
were synthesized through a five-step reaction sequence and evaluated for their β …
Novel 2, 5-disubtituted-1, 3, 4-oxadiazoles with benzimidazole backbone: a new class of β-glucuronidase inhibitors and in silico studies
Abstract A library of novel 2, 5-disubtituted-1, 3, 4-oxadiazoles with benzimidazole backbone
(3a–3r) was synthesized and evaluated for their potential as β-glucuronidase inhibitors …
(3a–3r) was synthesized and evaluated for their potential as β-glucuronidase inhibitors …
2-(2′-Pyridyl) benzimidazole derivatives and their urease inhibitory activity
Abstract Pyridyl-benzimidazole analogues 1–11 with variable substituent on phenyl ring of
phenacyl moiety were synthesized and evaluated for their urease inhibitory activity. The …
phenacyl moiety were synthesized and evaluated for their urease inhibitory activity. The …