Genetic variations resulting in a change of amino acid sequence can have a dramatic effect
on stability, hydrogen bond network, conformational dynamics, activity and many other …

Worldwide, familial and epidemiological studies have generated considerable evidence of
an inherited component to prostate cancer. Indeed, rare highly penetrant genetic mutations …

Deciphering the shared genetic basis of distinct cancers has the potential to elucidate
carcinogenic mechanisms and inform broadly applicable risk assessment efforts. Here, we …

Prostate cancer is the most frequently diagnosed cancer in males in developed countries. To
identify common prostate cancer susceptibility alleles, we genotyped 211,155 SNPs on a …

Aptamers are structured nucleic acid molecules that can bind to their targets with high affinity
and specificity. However, conventional SELEX (Systematic Evolution of Ligands by …

Human evolutionary history is rich with the interbreeding of divergent populations. Most
humans outside of Africa trace about 2% of their genomes to admixture from Neanderthals …

Although prostate cancer is the most common malignancy to affect men in the Western
world, the molecular mechanisms underlying its development and progression remain …

Since the proposition of the pro‐invasive activity of proteolytic enzymes over 70 years ago,
several roles for proteases in cancer progression have been established. About half of the …

Genome-wide association studies (GWAS) have been successful in deciphering the genetic
component of predisposition to many human complex diseases including prostate cancer …

Most men diagnosed with prostate cancer will experience indolent disease; hence,
discovering genetic variants that distinguish aggressive from nonaggressive prostate cancer …