Medicinal plants with concomitant anti-diabetic and anti-hypertensive effects as potential sources of dual acting therapies against diabetes and hypertension: A review

CI Chukwuma, MG Matsabisa, MA Ibrahim… - Journal of …, 2019 - Elsevier
Ethnopharmacological relevance Diabetes and hypertension are pathophysiologically
related diseases that co-exist with a wider complex of metabolic diseases having similar set …

Reduction of blood glucose by plant extracts and their use in the treatment of diabetes mellitus; discrepancies in effectiveness between animal and human studies

BL Furman, M Candasamy, SK Bhattamisra… - Journal of …, 2020 - Elsevier
Ethnopharmacological relevance The global problem of diabetes, together with the limited
access of large numbers of patients to conventional antidiabetic medicines, continues to …

Quercetin and/or Ascorbic Acid Modulatory Effect on Phenobarbital-Induced Slee** Mice Possibly through GABAA and GABAB Receptor Interaction Pathway

R Hossain, K Al-Khafaji, RA Khan, C Sarkar, MS Islam… - Pharmaceuticals, 2021 - mdpi.com
Depressive disorder is a recurrent illness that affects large numbers of the general
population worldwide. In recent years, the goal of depression treatment has moved from …

A comprehensive review on zinc (II) complexes as anti-diabetic agents: The advances, scientific gaps and prospects

CI Chukwuma, SS Mashele, KC Eze… - Pharmacological …, 2020 - Elsevier
Zinc has gained notable attention in the development of potent anti-diabetic agents, due to
its role in insulin storage and secretion, as well as its reported insulin mimetic properties …

Vernonia Amygdalina Del. stimulated glucose uptake in brain tissues enhances antioxidative activities; and modulates functional chemistry and dysregulated …

OL Erukainure, OA Oyebode, CU Ibeji… - Metabolic brain …, 2019 - Springer
Brain glucose uptake is usually reduced in type 2 diabetes owing to downregulation of brain
glucose transporters. The ability of Vernonia amygdalina to stimulate glucose uptake as well …

Oxidative testicular injury: effect of l-leucine on redox, cholinergic and purinergic dysfunctions, and dysregulated metabolic pathways

OL Erukainure, O Atolani, P Banerjee, R Abel, OJ Pooe… - Amino Acids, 2021 - Springer
The antioxidant and anti-proinflammatory activities of l-leucine were investigated on
oxidative testicular injury, ex vivo. In vitro analysis revealed l-leucine to be a potent …

African Vegetables (Clerodendrum volubile Leaf and Irvingia gabonensis Seed Extracts) Effectively Mitigate Trastuzumab‐Induced Cardiotoxicity in Wistar Rats

O Olorundare, A Adeneye, A Akinsola… - Oxidative Medicine …, 2020 - Wiley Online Library
Trastuzumab (TZM) is a humanized monoclonal antibody that has been approved for the
clinical management of HER2‐positive metastatic breast and gastric cancers but its use is …

Raffia palm (Raphia hookeri G. Mann & H. Wendl) wine modulates glucose homeostasis by enhancing insulin secretion and inhibiting redox imbalance in a rat model …

OL Erukainure, OA Oyebode, OM Ijomone… - Journal of …, 2019 - Elsevier
Abstract Ethnopharmacological relevance Raffia palm (Raphia hookeri) wine (RPW) is
amongst the natural products from plants, utilized singly or in combination with other …

The antidiabetic properties of the hot water extract of kola nut (Cola nitida (Vent.) Schott & Endl.) in type 2 diabetic rats

OL Erukainure, O Sanni, OM Ijomone, CU Ibeji… - Journal of …, 2019 - Elsevier
Ethnopharmacological relevance Cola nitida is amongst the evergreen plants native to West
Africa used in the treatment of various ailments including diabetes. Aim of the study: This …

[HTML][HTML] Kolaviron attenuates cardiovascular injury in fructose-streptozotocin induced type-2 diabetic male rats by reducing oxidative stress, inflammation, and …

JO Adoga, ML Channa, A Nadar - Biomedicine & Pharmacotherapy, 2021 - Elsevier
The prevalence of cardiovascular disease among type-2 diabetic patients has become a
source of major concern world over. This study explored the protective effect of kolaviron, a …