Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018

L Galluzzi, I Vitale, SA Aaronson, JM Abrams… - Cell Death & …, 2018 - nature.com
Over the past decade, the Nomenclature Committee on Cell Death (NCCD) has formulated
guidelines for the definition and interpretation of cell death from morphological, biochemical …

Molecular mechanisms of cell death in neurological diseases

D Moujalled, A Strasser, JR Liddell - Cell Death & Differentiation, 2021 - nature.com
Tightly orchestrated programmed cell death (PCD) signalling events occur during normal
neuronal development in a spatially and temporally restricted manner to establish the neural …

The MTT assay: utility, limitations, pitfalls, and interpretation in bulk and single-cell analysis

M Ghasemi, T Turnbull, S Sebastian… - International journal of …, 2021 - mdpi.com
The MTT assay for cellular metabolic activity is almost ubiquitous to studies of cell toxicity;
however, it is commonly applied and interpreted erroneously. We investigated the …

Ferroptosis in cancer and cancer immunotherapy

L Zhao, X Zhou, F **e, L Zhang, H Yan… - Cancer …, 2022 - Wiley Online Library
The hallmark of tumorigenesis is the successful circumvention of cell death regulation for
achieving unlimited replication and immortality. Ferroptosis is a newly identified type of cell …

The molecular machinery of regulated cell death

D Tang, R Kang, TV Berghe, P Vandenabeele… - Cell research, 2019 - nature.com
Cells may die from accidental cell death (ACD) or regulated cell death (RCD). ACD is a
biologically uncontrolled process, whereas RCD involves tightly structured signaling …

Pyroptosis: gasdermin-mediated programmed necrotic cell death

J Shi, W Gao, F Shao - Trends in biochemical sciences, 2017 - cell.com
Pyroptosis was long regarded as caspase-1-mediated monocyte death in response to
certain bacterial insults. Caspase-1 is activated upon various infectious and immunological …

Metallodrugs are unique: Opportunities and challenges of discovery and development

EJ Anthony, EM Bolitho, HE Bridgewater… - Chemical …, 2020 - pubs.rsc.org
Metals play vital roles in nutrients and medicines and provide chemical functionalities that
are not accessible to purely organic compounds. At least 10 metals are essential for human …

Sterile inflammation: sensing and reacting to damage

GY Chen, G Nuñez - Nature Reviews Immunology, 2010 - nature.com
Over the past several decades, much has been revealed about the nature of the host innate
immune response to microorganisms, with the identification of pattern recognition receptors …

Molecular definitions of cell death subroutines: recommendations of the Nomenclature Committee on Cell Death 2012

L Galluzzi, I Vitale, JM Abrams, ES Alnemri… - Cell Death & …, 2012 - nature.com
Abstract In 2009, the Nomenclature Committee on Cell Death (NCCD) proposed a set of
recommendations for the definition of distinct cell death morphologies and for the …

Cell biology of ischemia/reperfusion injury

T Kalogeris, CP Baines, M Krenz, RJ Korthuis - International review of cell …, 2012 - Elsevier
Disorders characterized by ischemia/reperfusion (I/R), such as myocardial infarction, stroke,
and peripheral vascular disease, continue to be among the most frequent causes of …