Intestinal fatty acid binding protein: A rising therapeutic target in lipid metabolism

X Huang, Y Zhou, Y Sun, Q Wang - Progress in Lipid Research, 2022 - Elsevier
Fatty acid binding proteins (FABPs) are key proteins in lipid transport, and the isoforms are
segregated according to their tissue origins. Several isoforms, such as adipose-FABP and …

Tissue-specific functions in the fatty acid-binding protein family

J Storch, AE Thumser - Journal of Biological Chemistry, 2010 - ASBMB
The intracellular fatty acid-binding proteins (FABPs) are abundantly expressed in almost all
tissues. They exhibit high affinity binding of a single long-chain fatty acid, with the exception …

Enterocyte fatty acid-binding proteins (FABPs): different functions of liver and intestinal FABPs in the intestine

AM Gajda, J Storch - Prostaglandins, Leukotrienes and Essential Fatty …, 2015 - Elsevier
Fatty acid-binding proteins (FABP) are highly abundant cytosolic proteins that are expressed
in most mammalian tissues. In the intestinal enterocyte, both liver-(LFABP; FABP1) and …

Serum I‐FABP as marker for enterocyte damage in coeliac disease and its relation to villous atrophy and circulating autoantibodies

MPM Adriaanse, GJ Tack, VL Passos… - Alimentary …, 2013 - Wiley Online Library
Background Enterocyte damage is the hallmark of coeliac disease (CD) resulting in
malabsorption. Little is known about the recovery of enterocyte damage and its clinical …

Functional cell models of the gut and their applications in food microbiology—a review

A Cencič, T Langerholc - International journal of food microbiology, 2010 - Elsevier
Animal experimentation has a long tradition for risk assessment of new drugs before they
reach the clinic. To reduce expensive animal experimentation, attempts have been made to …

Spatiotemporally resolved colorectal oncogenesis in mini-colons ex vivo

LF Lorenzo-Martín, T Hübscher, AD Bowler… - Nature, 2024 - nature.com
Three-dimensional organoid culture technologies have revolutionized cancer research by
allowing for more realistic and scalable reproductions of both tumour and …

Effects of silver nanoparticles and ions on a co-culture model for the gastrointestinal epithelium

A Georgantzopoulou, T Serchi, S Cambier… - Particle and fibre …, 2015 - Springer
Background The increased incorporation of silver nanoparticles (Ag NPs) into consumer
products makes the characterization of potential risk for humans and other organisms …

Transport and biological activities of bile acids

BL Zwicker, LB Agellon - The international journal of biochemistry & cell …, 2013 - Elsevier
Bile acids have emerged as important biological molecules that support the solubilization of
various lipids and lipid-soluble compounds in the gut, and the regulation of gene expression …

Abnormal small intestinal epithelial microvilli in patients with Crohn's disease

KL VanDussen, A Stojmirović, K Li, TC Liu, PK Kimes… - Gastroenterology, 2018 - Elsevier
Background & Aims Crohn disease (CD) presents as chronic and often progressive
intestinal inflammation, but the contributing pathogenic mechanisms are unclear. We aimed …

Intestinal CFTR expression alleviates meconium ileus in cystic fibrosis pigs

DA Stoltz, T Rokhlina, SE Ernst… - The Journal of …, 2013 - Am Soc Clin Investig
Cystic fibrosis (CF) pigs develop disease with features remarkably similar to those in people
with CF, including exocrine pancreatic destruction, focal biliary cirrhosis, micro-gallbladder …