Targeting ferroptosis as a vulnerability in cancer

G Lei, L Zhuang, B Gan - Nature Reviews Cancer, 2022 - nature.com
Ferroptosis is an iron-dependent form of regulated cell death that is triggered by the toxic
build-up of lipid peroxides on cellular membranes. In recent years, ferroptosis has garnered …

Autophagy mediates an amplification loop during ferroptosis

S Lee, N Hwang, BG Seok, S Lee, SJ Lee… - Cell Death & …, 2023 - nature.com
Ferroptosis, a programmed cell death, has been identified and associated with cancer and
various other diseases. Ferroptosis is defined as a reactive oxygen species (ROS) …

[HTML][HTML] Aspirin promotes RSL3-induced ferroptosis by suppressing mTOR/SREBP-1/SCD1-mediated lipogenesis in PIK3CA-mutant colorectal cancer

H Chen, Q Qi, N Wu, Y Wang, Q Feng, R **, L Jiang - Redox Biology, 2022 - Elsevier
Ferroptosis, a new form of regulated cell death triggered by the iron-dependent peroxidation
of phospholipids, is associated with cellular metabolism, redox homeostasis, and various …

Malic enzyme 1 as a novel anti‐ferroptotic regulator in hepatic ischemia/reperfusion injury

X Fang, J Zhang, Y Li, Y Song, Y Yu, Z Cai… - Advanced …, 2023 - Wiley Online Library
Ferroptosis has been linked to the pathogenesis of hepatic injury induced by
ischemia/reperfusion (I/R). However, the mechanistic basis remains unclear. In this study, by …

Nutritional and metabolic control of ferroptosis

E Mishima, M Conrad - Annual Review of Nutrition, 2022 - annualreviews.org
Ferroptosis is a type of regulated cell death characterized by an excessive lipid peroxidation
of cellular membranes caused by the disruption of the antioxidant defense system and/or an …

Targeting molecular mediators of ferroptosis and oxidative stress for neurological disorders

J Li, B Jia, Y Cheng, Y Song, Q Li… - Oxidative Medicine and …, 2022 - Wiley Online Library
With the acceleration of population aging, nervous system diseases including Alzheimer's
disease (AD), Parkinson's disease (PD), Huntington's disease (HD), anxiety, depression …

[HTML][HTML] Ferroptosis in cancer progression: role of noncoding RNAs

YB Zuo, YF Zhang, R Zhang, JW Tian… - … journal of biological …, 2022 - ncbi.nlm.nih.gov
Ferroptosis is a novel form of programmed cell death, and it is characterized by iron-
dependent oxidative damage, lipid peroxidation and reactive oxygen species accumulation …

Ferroptosis in cancer: From molecular mechanisms to therapeutic strategies

Q Zhou, Y Meng, D Li, L Yao, J Le, Y Liu… - … and Targeted Therapy, 2024 - nature.com
Ferroptosis is a non-apoptotic form of regulated cell death characterized by the lethal
accumulation of iron-dependent membrane-localized lipid peroxides. It acts as an innate …

International consensus guidelines for the definition, detection, and interpretation of autophagy-dependent ferroptosis

X Chen, AS Tsvetkov, HM Shen, C Isidoro… - Autophagy, 2024 - Taylor & Francis
Macroautophagy/autophagy is a complex degradation process with a dual role in cell death
that is influenced by the cell types that are involved and the stressors they are exposed to …

Hypersensitivity to ferroptosis in chromophobe RCC is mediated by a glutathione metabolic dependency and cystine import via solute carrier family 7 member 11

L Zhang, CS Hobeika, D Khabibullin… - Proceedings of the …, 2022 - National Acad Sciences
Chromophobe (Ch) renal cell carcinoma (RCC) arises from the intercalated cell in the distal
nephron. There are no proven treatments for metastatic ChRCC. A distinguishing …