Over the past three years (2020–2022) more structures of GPCRs have been determined
than in the previous twenty years (2000–2019), primarily of GPCR complexes that are large …

The activation of G protein-coupled receptors (GPCRs) is triggered by ligand binding to their
orthosteric sites, which induces ligand-specific conformational changes. Agonists and …

Many orphan G protein-coupled receptors (GPCRs) remain understudied because their
endogenous ligands are unknown. Here, we show that a group of class A/rhodopsin-like …

Photoactivatable neuropeptides offer a robust stimulus–response relationship that can drive
mechanistic studies into the physiological mechanisms of neuropeptidergic transmission …

The small cyclic neuropeptide hormone oxytocin (OT) and its cognate receptor play a central
role in the regulation of social behaviour and sexual reproduction. Here we report the single …

Simple Summary Improving the response, quality of life and survival of oncologic patients
through the design and application of the most appropriate treatment for each case is a great …

The substance P (SP)/neurokinin-1 receptor (NK-1R) system is involved in cancer
progression. NK-1R, activated by SP, promotes tumor cell proliferation and migration …

Simple Summary Neurokinins A and B, adrenomedullin, adrenomedullin 2, amylin, and
calcitonin gene-related peptide are essential in different tumors. These peptides are …

Ticks are blood-feeding arthropods that require heme for their successful reproduction.
During feeding they also acquire pathogens that are subsequently transmitted to humans …

GPCRs form a very large family of transmembrane proteins involved in a wide range of
physiological functions. Some GPCRs have their activity affected by the presence of …