Osteocyte-related cytokines regulate osteoclast formation and bone resorption
H Kitaura, A Marahleh, F Ohori, T Noguchi… - International journal of …, 2020 - mdpi.com
The process of bone remodeling is the result of the regulated balance between bone cell
populations, namely bone-forming osteoblasts, bone-resorbing osteoclasts, and the …
populations, namely bone-forming osteoblasts, bone-resorbing osteoclasts, and the …
Skeletal aging and osteoporosis: mechanisms and therapeutics
A Chandra, J Rajawat - International journal of molecular sciences, 2021 - mdpi.com
Bone is a dynamic organ maintained by tightly regulated mechanisms. With old age, bone
homeostasis, which is maintained by an intricate balance between bone formation and bone …
homeostasis, which is maintained by an intricate balance between bone formation and bone …
Single cell transcriptomics identifies a unique adipose lineage cell population that regulates bone marrow environment
Bone marrow mesenchymal lineage cells are a heterogeneous cell population involved in
bone homeostasis and diseases such as osteoporosis. While it is long postulated that they …
bone homeostasis and diseases such as osteoporosis. While it is long postulated that they …
[HTML][HTML] Bone marrow adipogenic lineage precursors promote osteoclastogenesis in bone remodeling and pathologic bone loss
Bone is maintained by coupled activities of bone-forming osteoblasts/osteocytes and bone-
resorbing osteoclasts. Alterations in this relationship can lead to pathologic bone loss such …
resorbing osteoclasts. Alterations in this relationship can lead to pathologic bone loss such …
Bone aging, cellular senescence, and osteoporosis
RJ Pignolo, SF Law, A Chandra - Journal of Bone and Mineral …, 2021 - academic.oup.com
Changes in aging bone that lead to osteoporosis are mediated at multiple levels, including
hormonal alterations, skeletal unloading, and accumulation of senescent cells. This …
hormonal alterations, skeletal unloading, and accumulation of senescent cells. This …
Clinical implications of bone marrow adiposity
AG Veldhuis‐Vlug, CJ Rosen - Journal of internal medicine, 2018 - Wiley Online Library
Marrow adipocytes, collectively termed marrow adipose tissue (MAT), reside in the bone
marrow in close contact to bone cells and haematopoietic cells. Marrow adipocytes arise …
marrow in close contact to bone cells and haematopoietic cells. Marrow adipocytes arise …
The pathophysiology of osteoporosis in obesity and type 2 diabetes in aging women and men: The mechanisms and roles of increased bone marrow adiposity
Osteoporosis is defined as a systemic skeletal disease characterized by decreased bone
mass and micro-architectural deterioration leading to increased fracture risk. Osteoporosis …
mass and micro-architectural deterioration leading to increased fracture risk. Osteoporosis …
Targeted clearance of p21‐ but not p16‐positive senescent cells prevents radiation‐induced osteoporosis and increased marrow adiposity
Cellular senescence, which is a major cause of tissue dysfunction with aging and multiple
other conditions, is known to be triggered by p16Ink4a or p21Cip1, but the relative …
other conditions, is known to be triggered by p16Ink4a or p21Cip1, but the relative …
Long-term endocrine and metabolic consequences of cancer treatment: a systematic review
The number of patients surviving≥ 5 years after initial cancer diagnosis has significantly
increased during the last decades due to considerable improvements in the treatment of …
increased during the last decades due to considerable improvements in the treatment of …
DNA damage and senescence in osteoprogenitors expressing Osx1 may cause their decrease with age
Age‐related bone loss in mice results from a decrease in bone formation and an increase in
cortical bone resorption. The former is accounted by a decrease in the number of postmitotic …
cortical bone resorption. The former is accounted by a decrease in the number of postmitotic …