Genetics of human primary hypertension: focus on hormonal mechanisms

W Manosroi, GH Williams - Endocrine reviews, 2019 - academic.oup.com
Increasingly, primary hypertension is being considered a syndrome and not a disease, with
the individual causes (diseases) having a common sign—an elevated blood pressure. To …

When blood pressure refuses to budge: exploring the complexity of resistant hypertension

MK Champaneria, RS Patel, TL Oroszi - Frontiers in cardiovascular …, 2023 - frontiersin.org
Resistant hypertension, defined as blood pressure that remains above goal despite using
three or more antihypertensive medications, including a diuretic, affects a significant …

A genome-wide association study identifies a novel candidate locus at the DLGAP1 gene with susceptibility to resistant hypertension in the Japanese population

Y Takahashi, K Yamazaki, Y Kamatani, M Kubo… - Scientific Reports, 2021 - nature.com
Numerous genetic variants associated with hypertension and blood pressure are known, but
there is a paucity of evidence from genetic studies of resistant hypertension, especially in …

Managing resistant hypertension: focus on mineralocorticoid-receptor antagonists

JC Yugar-Toledo, R Modolo, AP de Faria… - Vascular health and …, 2017 - Taylor & Francis
Mineralocorticoid-receptor antagonists (MRAs) have proven to be effective in some types of
hypertension, especially in resistant hypertension (RHTN). In this phenotype of …

Excessive dietary sodium intake and elevated blood pressure: a review of current prevention and management strategies and the emerging role of …

OM Dong - BMJ nutrition, prevention & health, 2018 - pmc.ncbi.nlm.nih.gov
INTRODUCTION Precision medicine has the potential to improve current standard of care
for patients, especially in the cardiovascular field. Better prevention and treatment of …

Resistant hypertension: new insights and therapeutic perspectives

LM Ruilope, E Rodríguez-Sánchez… - European Heart …, 2020 - academic.oup.com
Resistant hypertension (RH) is a concept that currently goes beyond the classical definition
of blood pressure≥ 140/90 mmHg in subjects receiving three or more drugs of different …

[HTML][HTML] Gene polymorphisms of the renin-angiotensin-aldosterone system as risk factors for the development of in-stent restenosis in patients with stable coronary …

M Azova, K Timizheva, A Ait Aissa, M Blagonravov… - Biomolecules, 2021 - mdpi.com
This study investigated the renin-angiotensin-aldosterone system (RAAS) gene
polymorphisms as possible genetic risk factors for the restenosis development in patients …

Resistant or refractory hypertension: are they different?

R Modolo, AP de Faria, A Almeida… - Current hypertension …, 2014 - Springer
Resistant hypertension (RHTN) consists in a condition where blood pressure (BP) levels
remain uncontrolled despite the use of at least three drugs or if the control happens with four …

Genetics of resistant hypertension: a novel pharmacogenomics phenotype

N El Rouby, RM Cooper-DeHoff - Current hypertension reports, 2015 - Springer
Resistant hypertension (RHTN), defined as an uncontrolled blood pressure despite the use
of multiple antihypertensive medications, is an increasing clinical problem associated with …

Association of mineralocorticoid receptor polymorphism I180V with left ventricular hypertrophy in resistant hypertension

AMV Ritter, V Fontana, APC de Faria… - American journal of …, 2016 - academic.oup.com
OBJECTIVES Genetic polymorphisms on mineralocorticoid receptor gene (NC3C2) are
associated with variability of mineralocorticoid receptor (MR) function and cardiovascular …