Current developments in nanotechnology for improved cancer treatment, focusing on tumor hypoxia
Hypoxia is a common feature of the tumor microenvironment, which is characterized by
tissue oxygen deficiency due to an aggressive proliferation of cancer cells. Hypoxia …
tissue oxygen deficiency due to an aggressive proliferation of cancer cells. Hypoxia …
Polymeric nanocapsules: A review on design and production methods for pharmaceutical purpose
Polymeric nanocapsules have extensive application potential in medical, biological, and
pharmaceutical fields, and, therefore, much research has been dedicated to their production …
pharmaceutical fields, and, therefore, much research has been dedicated to their production …
Acriflavine, an acridine derivative for biomedical application: current state of the art
K Piorecka, J Kurjata, WA Stanczyk - Journal of Medicinal …, 2022 - ACS Publications
Acriflavine (ACF) has been known for years as an antibacterial drug. The identification of key
oncogenic mechanisms has brought, in recent years, a significant increase in studies on …
oncogenic mechanisms has brought, in recent years, a significant increase in studies on …
[HTML][HTML] From lab to industrial development of lipid nanocarriers using quality by design approach
Lipid nanocarriers have attracted a great deal of interest in the delivery of therapeutic
molecules. Despite their many advantages, compliance with quality standards and …
molecules. Despite their many advantages, compliance with quality standards and …
The role of imaging biomarkers to guide pharmacological interventions targeting tumor hypoxia
B Gallez - Frontiers in pharmacology, 2022 - frontiersin.org
Hypoxia is a common feature of solid tumors that contributes to angiogenesis, invasiveness,
metastasis, altered metabolism and genomic instability. As hypoxia is a major actor in tumor …
metastasis, altered metabolism and genomic instability. As hypoxia is a major actor in tumor …
Nanomedicines for overcoming cancer drug resistance
T Hu, H Gong, J Xu, Y Huang, F Wu, Z He - Pharmaceutics, 2022 - mdpi.com
Clinically, cancer drug resistance to chemotherapy, targeted therapy or immunotherapy
remains the main impediment towards curative cancer therapy, which leads directly to …
remains the main impediment towards curative cancer therapy, which leads directly to …
Enhanced oral bioavailability of Tanshinone IIA using lipid nanocapsules: formulation, in-vitro appraisal and pharmacokinetics
Tanshinone IIA (TSIIA) is a promising phytomedicine that has been extensively studied due
to its numerous biological activities, especially as an anticancer drug. However, it suffers …
to its numerous biological activities, especially as an anticancer drug. However, it suffers …
Engineering nanomedicines to inhibit hypoxia-inducible Factor-1 for cancer therapy
X Zhang, C He, G **ang - Cancer Letters, 2022 - Elsevier
Abstract Hypoxia-inducible factor-1 (HIF-1), an essential promoter of tumor progression, has
attracted increasing attention as a therapeutic target. In addition to hypoxic cellular …
attracted increasing attention as a therapeutic target. In addition to hypoxic cellular …
Switching indication of PEGylated lipid nanocapsules-loaded with rolapitant and deferasirox against breast cancer: Enhanced in-vitro and in-vivo cytotoxicity
Breast cancer (BC) is considered the leading cause of mortality and morbidity among adult
women worldwide, and it is associated with many genetic or hormonal factors. Despite the …
women worldwide, and it is associated with many genetic or hormonal factors. Despite the …
Applications of lipid-engineered nanoplatforms in the delivery of various cancer therapeutics to surmount breast cancer
Breast cancer (BC) is the most extensively accounted malignancy among the women across
the globe and is treatable in 70–80% of patients with early-stage, non-metastatic cancer …
the globe and is treatable in 70–80% of patients with early-stage, non-metastatic cancer …