Neurogenesis persists in adult mammals in specific brain areas, known as neurogenic
niches. Adult neurogenesis is highly dynamic and is modulated by multiple physiological …

Transcriptional regulation is essential for the correct functioning of cells during development
and in postnatal life. The basic Helix-loop-Helix (bHLH) superfamily of transcription factors is …

Summary N 6-methyladenosine (m 6 A), installed by the Mettl3/Mettl14 methyltransferase
complex, is the most prevalent internal mRNA modification. Whether m 6 A regulates …

Radial glia, the neural stem cells of the neocortex, are located in two niches: the ventricular
zone and outer subventricular zone. Although outer subventricular zone radial glia may …

Classical lissencephaly is a genetic neurological disorder associated with mental
retardation and intractable epilepsy, and Miller-Dieker syndrome (MDS) is the most severe …

The cerebral cortex of large mammals undergoes massive surface area expansion and
folding during development. Specific mechanisms to orchestrate the growth of the cortex in …

Metabolism has recently emerged as a major target of genes implicated in the evolutionary
expansion of human neocortex. One such gene is the human-specific gene ARHGAP11B …

Differentiated cells have long been considered fixed in their identity. However, about 20
years ago, the first direct conversion of glial cells into neurons in vitro opened the field of" …

Astroglia from the postnatal cerebral cortex can be reprogrammed in vitro to generate
neurons following forced expression of neurogenic transcription factors, thus opening new …

The cerebral neocortex is segregated into six horizontal layers, each containing unique
populations of molecularly and functionally distinct excitatory projection (pyramidal) neurons …