Since Hedin's characterization of trypsin and antitrypsin in 1906,(1) arguably the first
account of a regulatory protein–protein interaction (PPI), contemporary understanding of …

Fungi have traditionally been a very rewarding source of biologically active natural products,
while diterpenoids from fungi, such as the cyathane-type diterpenoids from Cyathus and …

The structure–stability relationships of 1–6 were investigated to show that 1 converted to 5
via a kinetic, solution-mediated autoxidation. In addition, alterbrassicene A (7), a …

Abstract Alterbrassicicene D (1) and 3 (11)‐epoxyhypoestenone (2) were synthesised via a
two‐phase approach featuring concise construction of the 5‐8‐5 tricyclic intermediate and a …

Highlights•Protein–protein interactions (PPIs) are ever increasingly targets for drug
discovery.•Targeted small molecule inhibition of PPIs has repeatedly been shown to be …

Covering: January to December 2013. Previous review, Nat. Prod. Rep., 2013, 30, 1346–
1356 This review covers the isolation and chemistry of diterpenoids from terrestrial as …

The use of silver nitrate as a chromatography support to better facilitate difficult separations
of organic compounds, is a technique that has been widely applied since Morris, 1 de Vries …

The metabolites from the endophytic fungus Talaromyces malicola hosted in the
gastrointestinal tract of the arthropods Armadillidium vulgare were investigated, and six …

Fungal secondary metabolites (FSMs) represent a remarkable array of bioactive
compounds, with potential applications as pharmaceuticals, nutraceuticals, and …

Abstract Ophiobolins (ophs) are characteristic 5-8-5 tricyclic sesterterpenes with potential
pharmaceutical activities. Ophiobolin synthase is a bifunctional terpene synthase (BTS) that …