Streptococcus pneumoniae (pneumococcus) is a major cause of worldwide mortality and
morbidity, and to a large extent is vaccine-preventable. Nasopharyngeal carriage of …

Pore-forming toxins (PFTs) are the most common bacterial cytotoxic proteins and are
required for virulence in a large number of important pathogens, including Streptococcus …

The circadian system is an important regulator of immune function. Human inflammatory
lung diseases frequently show time-of-day variation in symptom severity and lung function …

Pneumococcus remains the most common cause of community-acquired pneumonia
worldwide. Streptococcus pneumoniae is well adapted to people, and is a frequent …

Streptococcus pneumoniae is a Gram-positive bacterial pathogen that colonizes the
mucosal surfaces of the host nasopharynx and upper airway. Through a combination of …

Streptococcus pneumoniae is a major pathogen causing pneumonia with over 2 million
deaths annually, especially in young children and the elderly. To date, at least 98 different …

Streptococcus pneumoniae is a major pathogen of humans, causing diseases such as
pneumonia and meningitis. The organism produces several virulence factors that are …

Pneumolysin (PLY) is a key Streptococcus pneumoniae virulence factor and potential
candidate for inclusion in pneumococcal subunit vaccines. Dendritic cells (DC) play a key …

Neisseria species are frequently identified in the bronchiectasis microbiome, but they are
regarded as respiratory commensals. Using a combination of human cohorts, next …

Secondary bacterial infections are a leading cause of illness and death during epidemic and
pandemic influenza. Experimental studies suggest a lethal synergism between influenza …