microRNAs in action: biogenesis, function and regulation

R Shang, S Lee, G Senavirathne, EC Lai - Nature Reviews Genetics, 2023 - nature.com
Ever since microRNAs (miRNAs) were first recognized as an extensive gene family> 20
years ago, a broad community of researchers was drawn to investigate the universe of small …

Long non-coding RNAs: definitions, functions, challenges and recommendations

JS Mattick, PP Amaral, P Carninci… - … reviews Molecular cell …, 2023 - nature.com
Genes specifying long non-coding RNAs (lncRNAs) occupy a large fraction of the genomes
of complex organisms. The term 'lncRNAs' encompasses RNA polymerase I (Pol I), Pol II …

Accurate prediction of protein–nucleic acid complexes using RoseTTAFoldNA

M Baek, R McHugh, I Anishchenko, H Jiang, D Baker… - Nature …, 2024 - nature.com
Protein–RNA and protein–DNA complexes play critical roles in biology. Despite
considerable recent advances in protein structure prediction, the prediction of the structures …

trRosettaRNA: automated prediction of RNA 3D structure with transformer network

W Wang, C Feng, R Han, Z Wang, L Ye, Z Du… - Nature …, 2023 - nature.com
RNA 3D structure prediction is a long-standing challenge. Inspired by the recent
breakthrough in protein structure prediction, we developed trRosettaRNA, an automated …

FlyBase: updates to the Drosophila genes and genomes database

A Öztürk-Çolak, SJ Marygold, G Antonazzo, H Attrill… - Genetics, 2024 - academic.oup.com
FlyBase (flybase. org) is a model organism database and knowledge base about Drosophila
melanogaster, commonly known as the fruit fly. Researchers from around the world rely on …

The status of the human gene catalogue

P Amaral, S Carbonell-Sala, FM De La Vega, T Faial… - Nature, 2023 - nature.com
Scientists have been trying to identify every gene in the human genome since the initial draft
was published in 2001. In the years since, much progress has been made in identifying …

Genenames. org: the HGNC resources in 2023

RL Seal, B Braschi, K Gray, TEM Jones… - Nucleic Acids …, 2023 - academic.oup.com
Abstract The HUGO Gene Nomenclature Committee (HGNC) assigns unique symbols and
names to human genes. The HGNC database (www. genenames. org) currently contains …

Multi-purpose RNA language modelling with motif-aware pretraining and type-guided fine-tuning

N Wang, J Bian, Y Li, X Li, S Mumtaz, L Kong… - Nature Machine …, 2024 - nature.com
Pretrained language models have shown promise in analysing nucleotide sequences, yet a
versatile model excelling across diverse tasks with a single pretrained weight set remains …

tRNAscan-SE 2.0: improved detection and functional classification of transfer RNA genes

PP Chan, BY Lin, AJ Mak, TM Lowe - Nucleic acids research, 2021 - academic.oup.com
Abstract tRNAscan-SE has been widely used for transfer RNA (tRNA) gene prediction for
over twenty years, developed just as the first genomes were decoded. With the massive …

Accurate RNA 3D structure prediction using a language model-based deep learning approach

T Shen, Z Hu, S Sun, D Liu, F Wong, J Wang, J Chen… - Nature …, 2024 - nature.com
Accurate prediction of RNA three-dimensional (3D) structures remains an unsolved
challenge. Determining RNA 3D structures is crucial for understanding their functions and …